ArticleFrontiers in physiology2022
Human Hypertension Blood Flow Model Using Fractional Calculus.
Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 19 citations in OpenAlex.
- A nonlinear windkessel model for cardiovascular dynamics: Variable compliance and pathological simulations.Medical & biological engineering & computing · 2026Article
- Fractional-Order Modeling of Arterial Compliance in Vascular Aging: A Computational Biomechanical Approach for Investigating Cardiovascular Dynamics.IEEE open journal of engineering in medicine and biology · 2024Article
- Parameter Sensitivity and Experimental Validation for Fractional-Order Dynamical Modeling of Neurovascular Coupling.IEEE open journal of engineering in medicine and biology · 2022Article
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
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Abstract
The blood flow dynamics in human arteries with hypertension disease is modeled using fractional calculus. The mathematical model is constructed using five-element lumped parameter arterial Windkessel representation. Fractional-order capacitors are used to represent the elastic properties of both proximal large arteries and distal small arteries measured from the heart aortic root. The proposed fractional model offers high flexibility in characterizing the arterial complex tree network. The results illustrate the validity of the new model and the physiological interpretability of the fractional differentiation order through a set of validation using human hypertensive patients. In addition, the results show that the fractional-order modeling approach yield a great potential to improve the understanding of the structural and functional changes in the large and small arteries due to hypertension disease.
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