Evidence map›Paper›PMID 35392269›Full record

ArticleFrontiers in molecular neuroscience2022

Blood-Based miRNA Biomarkers as Correlates of Brain-Based miRNA Expression.

Mark Z Kos, Sobha Puppala, Dianne Cruz, Jennifer L Neary, Ashish Kumar, Emma Dalan, Cun Li, Peter Nathanielsz, Melanie A Carless

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Small Differences and Big Changes: The Many Variables of MicroRNA Expression and Function in the Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Review
  10. Review
  11. Article
  12. Finding biomarkers of experience in animals.Journal of animal science and biotechnology · 2024
    Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Clinical Utility of Fluid Biomarker in Depressive Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Mark Z KosDepartment of Human Genetics, South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Edinburg, TX, United States.
Sobha PuppalaDepartment of Internal Medicine-Section of Molecular Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC, United States.
Dianne CruzDuke University School of Medicine, Durham, NC, United States.
Jennifer L NearyDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, United States.
Ashish KumarDepartment of Internal Medicine-Section of Molecular Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC, United States.
Emma DalanDepartment of Biology, University of Texas at San Antonio, San Antonio, TX, United States.
Cun LiSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, United States.
Peter NathanielszSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, United States.
Melanie A CarlessDepartment of Biology, University of Texas at San Antonio, San Antonio, TX, United States.
Atrium Health Wake Forest Baptist · USTexas Biomedical Research Institute · USThe University of Texas at San Antonio · USDuke University · USSt. Jude Children's Research Hospital · USThe University of Texas Rio Grande Valley · US

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
NIH HHS P51 OD011133
6 · The paper itself

Abstract

The use of easily accessible peripheral samples, such as blood or saliva, to investigate neurological and neuropsychiatric disorders is well-established in genetic and epigenetic research, but the pathological implications of such biomarkers are not easily discerned. To better understand the relationship between peripheral blood- and brain-based epigenetic activity, we conducted a pilot study on captive baboons (

Indexed as

baboonbloodbraincorrelationmiRNA expressionsequencing

Identifiers

PMID35392269
PMCPMC8981579
OpenAlexW4220903702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.