Evidence map›Paper›PMID 35392232›Full record

ArticleFrontiers in oncology2022

Glycerophosphoinositol Promotes Apoptosis of Chronic Lymphocytic Leukemia Cells by Enhancing Bax Expression and Activation.

Gioia Boncompagni, Alessia Varone, Vanessa Tatangelo, Nagaja Capitani, Federica Frezzato, Andrea Visentin, Livio Trentin, Daniela Corda, Cosima T Baldari, Laura Patrussi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Gioia BoncompagniDepartment of Life Sciences, University of Siena, Siena, Italy.
Alessia VaroneInstitute of Endocrinology and Experimental Oncology "G. Salvatore", National Research Council, Naples, Italy.
Vanessa TatangeloDepartment of Life Sciences, University of Siena, Siena, Italy.
Nagaja CapitaniDepartment of Life Sciences, University of Siena, Siena, Italy.
Federica FrezzatoHematology and Clinical Immunology Unit, Department of Medicine, University of Padua, Padua, Italy.
Andrea VisentinHematology and Clinical Immunology Unit, Department of Medicine, University of Padua, Padua, Italy.
Livio TrentinHematology and Clinical Immunology Unit, Department of Medicine, University of Padua, Padua, Italy.
Daniela CordaDepartment of Biomedical Sciences, National Research Council, Rome, Italy.
Cosima T BaldariDepartment of Life Sciences, University of Siena, Siena, Italy.
Laura PatrussiDepartment of Life Sciences, University of Siena, Siena, Italy.
University of Siena · ITUniversity of Padua · ITNational Research Council · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An imbalance in the expression of pro- and anti-apoptotic members of the Bcl-2 family of apoptosis-regulating proteins is one of the main biological features of CLL, highlighting these proteins as therapeutic targets for treatment of this malignancy. Indeed, the Bcl-2 inhibitor Venetoclax is currently used for both first-line treatment and treatment of relapsed or refractory CLL. An alternative avenue is the transcriptional modulation of Bcl-2 family members to tilt their balance towards apoptosis. Glycerophosphoinositol (GroPIns) is a biomolecule generated from membrane phosphoinositides by the enzymes phospholipase A

Indexed as

apoptosisBaxCLLglycerophosphoinositolSHP-1

Identifiers

PMID35392232
PMCPMC8980805
OpenAlexW4220784911

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.