Evidence map›Paper›PMID 35392033›Full record

ArticleFrontiers in aging2022

Age-Related Intestinal Dysbiosis and Enrichment of Gut-specific Bacteria in the Lung Are Associated With Increased Susceptibility to

Rachel H McMahan, Holly J Hulsebus, Kevin M Najarro, Lauren E Giesy, Daniel N Frank, David J Orlicky, Elizabeth J Kovacs

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Impaired intestinal cell proliferation parallels increased senescence after burn injury in aged mice.American journal of physiology. Gastrointestinal and liver physiology · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Reducing the excessive inflammation after burn injury in aged mice by maintaining a healthier intestinal microbiome.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Rachel H McMahanDepartment of Surgery, Division of GI, Trauma and Endocrine Surgery, and Alcohol Research Program, Burn Research Program, University of Colorado Denver, Aurora, CO, United States.
Holly J HulsebusDepartment of Surgery, Division of GI, Trauma and Endocrine Surgery, and Alcohol Research Program, Burn Research Program, University of Colorado Denver, Aurora, CO, United States.
Kevin M NajarroDepartment of Surgery, Division of GI, Trauma and Endocrine Surgery, and Alcohol Research Program, Burn Research Program, University of Colorado Denver, Aurora, CO, United States.
Lauren E GiesyDepartment of Surgery, Division of GI, Trauma and Endocrine Surgery, and Alcohol Research Program, Burn Research Program, University of Colorado Denver, Aurora, CO, United States.
Daniel N FrankGI and Liver Innate Immune Program, University of Colorado Denver, Aurora, CO, United States.
David J OrlickyGI and Liver Innate Immune Program, University of Colorado Denver, Aurora, CO, United States.
Elizabeth J KovacsDepartment of Surgery, Division of GI, Trauma and Endocrine Surgery, and Alcohol Research Program, Burn Research Program, University of Colorado Denver, Aurora, CO, United States.
University of Colorado Denver · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Aging, macrophage mediators, and burn trauma: SupplementR01AG018859 · NIA · UNIVERSITY OF COLORADO DENVER · PI KOVACS, ELIZABETH J. · 2001 to 2024
$7.6M
Alcohol and Burn Trauma: Multi-organ Inflammatory ResponsesR35GM131831 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI ELIZABETH J. KOVACS · 2019 to 2026
$3.5M
Alcohol and Lung Immunity in the AgedR21AA026295 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI KOVACS, ELIZABETH J. · 2018 to 2019
$408k
Ethanol effects on pulmonary innate immunity in a murine model of agingF31AA027687 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI HULSEBUS, HOLLY J · 2019 to 2021
$101k
BLRD VA I01 BX004335NIAAA NIH HHS F31 AA027687NIAAA NIH HHS R21 AA026295NIA NIH HHS R01 AG018859NIGMS NIH HHS R35 GM131831
6 · The paper itself

Abstract

The portion of the global population that is over the age of 65 is growing rapidly and this presents a number of clinical complications, as the aged population is at higher risk for various diseases, including infection. For example, advanced age is a risk factor for heightened morbidity and mortality following infection with

Indexed as

aginggut-lung axisinnate immunitymicrobiomeneutrophilpneumonia

Identifiers

PMID35392033
PMCPMC8986162
OpenAlexW4220785099

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.