ArticleRadiology. Artificial intelligence2022
Deep Learning-based Automatic Lung Segmentation on Multiresolution CT Scans from Healthy and Fibrotic Lungs in Mice.
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Article in Radiology. Artificial intelligence, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Multidimensional lung imaging: integrated preclinical platforms enabling the identification of translational biomarkers for pulmonary research.Respiratory research · 2026Review
- A multi-stage 3D convolutional neural network algorithm for CT-based lung segment parcellation.Journal of applied clinical medical physics · 2025Article
- External validation, radiological evaluation, and development of deep learning automatic lung segmentation in contrast-enhanced chest CT.European radiology · 2024Article
- Three-Dimensional Measurement of the Uterus on Magnetic Resonance Images: Development and Performance Analysis of an Automated Deep-Learning Tool.Diagnostics (Basel, Switzerland) · 2023Article
- Assessment of Variabilities in Lung-Contouring Methods on CBCT Preclinical Radiomics Outputs.Cancers · 2023Article
- Article
- A fully automated deep learning pipeline for micro-CT-imaging-based densitometry of lung fibrosis murine models.Respiratory research · 2022Article
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Authors and funding
14 authors.
Francesco SforazziniClinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Department of Radiation Oncology (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.) and National Center for Tumor Diseases (NCT) (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.), Heidelberg University Hospital (UKHD), Heidelberg, Germany; German Cancer Consortium (DKTK) Core Center Heidelberg, Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., J.D., A.A., M.K.); National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.); Department of Clinical Pathology, Suez Canal University, Ismailia, Egypt (M.M.); Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z.); and The D-Laboratory and the M-Laboratory, Department of Precision Medicine, GROW-School for Oncology, Maastricht University, Maastricht, the Netherlands (H.W., L.D., P.L.).ORCID https://orcid.org/0000-0003-2011-9394
Patrick SalomeClinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Department of Radiation Oncology (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.) and National Center for Tumor Diseases (NCT) (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.), Heidelberg University Hospital (UKHD), Heidelberg, Germany; German Cancer Consortium (DKTK) Core Center Heidelberg, Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., J.D., A.A., M.K.); National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.); Department of Clinical Pathology, Suez Canal University, Ismailia, Egypt (M.M.); Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z.); and The D-Laboratory and the M-Laboratory, Department of Precision Medicine, GROW-School for Oncology, Maastricht University, Maastricht, the Netherlands (H.W., L.D., P.L.).ORCID 0000-0003-4978-9156
Mahmoud MoustafaClinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Department of Radiation Oncology (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.) and National Center for Tumor Diseases (NCT) (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.), Heidelberg University Hospital (UKHD), Heidelberg, Germany; German Cancer Consortium (DKTK) Core Center Heidelberg, Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., J.D., A.A., M.K.); National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.); Department of Clinical Pathology, Suez Canal University, Ismailia, Egypt (M.M.); Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z.); and The D-Laboratory and the M-Laboratory, Department of Precision Medicine, GROW-School for Oncology, Maastricht University, Maastricht, the Netherlands (H.W., L.D., P.L.).
Cheng ZhouClinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Department of Radiation Oncology (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.) and National Center for Tumor Diseases (NCT) (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.), Heidelberg University Hospital (UKHD), Heidelberg, Germany; German Cancer Consortium (DKTK) Core Center Heidelberg, Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., J.D., A.A., M.K.); National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.); Department of Clinical Pathology, Suez Canal University, Ismailia, Egypt (M.M.); Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z.); and The D-Laboratory and the M-Laboratory, Department of Precision Medicine, GROW-School for Oncology, Maastricht University, Maastricht, the Netherlands (H.W., L.D., P.L.).
Christian SchwagerClinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Department of Radiation Oncology (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.) and National Center for Tumor Diseases (NCT) (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.), Heidelberg University Hospital (UKHD), Heidelberg, Germany; German Cancer Consortium (DKTK) Core Center Heidelberg, Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., J.D., A.A., M.K.); National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.); Department of Clinical Pathology, Suez Canal University, Ismailia, Egypt (M.M.); Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z.); and The D-Laboratory and the M-Laboratory, Department of Precision Medicine, GROW-School for Oncology, Maastricht University, Maastricht, the Netherlands (H.W., L.D., P.L.).ORCID 0000-0003-4945-0347
Katrin ReinClinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Department of Radiation Oncology (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.) and National Center for Tumor Diseases (NCT) (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.), Heidelberg University Hospital (UKHD), Heidelberg, Germany; German Cancer Consortium (DKTK) Core Center Heidelberg, Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., J.D., A.A., M.K.); National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.); Department of Clinical Pathology, Suez Canal University, Ismailia, Egypt (M.M.); Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z.); and The D-Laboratory and the M-Laboratory, Department of Precision Medicine, GROW-School for Oncology, Maastricht University, Maastricht, the Netherlands (H.W., L.D., P.L.).
Nina BougatfClinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Department of Radiation Oncology (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.) and National Center for Tumor Diseases (NCT) (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.), Heidelberg University Hospital (UKHD), Heidelberg, Germany; German Cancer Consortium (DKTK) Core Center Heidelberg, Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., J.D., A.A., M.K.); National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.); Department of Clinical Pathology, Suez Canal University, Ismailia, Egypt (M.M.); Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z.); and The D-Laboratory and the M-Laboratory, Department of Precision Medicine, GROW-School for Oncology, Maastricht University, Maastricht, the Netherlands (H.W., L.D., P.L.).ORCID 0000-0002-0718-7360
Andreas KudakClinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Department of Radiation Oncology (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.) and National Center for Tumor Diseases (NCT) (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.), Heidelberg University Hospital (UKHD), Heidelberg, Germany; German Cancer Consortium (DKTK) Core Center Heidelberg, Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., J.D., A.A., M.K.); National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.); Department of Clinical Pathology, Suez Canal University, Ismailia, Egypt (M.M.); Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z.); and The D-Laboratory and the M-Laboratory, Department of Precision Medicine, GROW-School for Oncology, Maastricht University, Maastricht, the Netherlands (H.W., L.D., P.L.).ORCID 0000-0002-1474-1403
Henry WoodruffClinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Department of Radiation Oncology (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.) and National Center for Tumor Diseases (NCT) (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.), Heidelberg University Hospital (UKHD), Heidelberg, Germany; German Cancer Consortium (DKTK) Core Center Heidelberg, Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., J.D., A.A., M.K.); National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.); Department of Clinical Pathology, Suez Canal University, Ismailia, Egypt (M.M.); Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z.); and The D-Laboratory and the M-Laboratory, Department of Precision Medicine, GROW-School for Oncology, Maastricht University, Maastricht, the Netherlands (H.W., L.D., P.L.).ORCID 0000-0001-7911-5123
Ludwig DuboisClinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Department of Radiation Oncology (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.) and National Center for Tumor Diseases (NCT) (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.), Heidelberg University Hospital (UKHD), Heidelberg, Germany; German Cancer Consortium (DKTK) Core Center Heidelberg, Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., J.D., A.A., M.K.); National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.); Department of Clinical Pathology, Suez Canal University, Ismailia, Egypt (M.M.); Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z.); and The D-Laboratory and the M-Laboratory, Department of Precision Medicine, GROW-School for Oncology, Maastricht University, Maastricht, the Netherlands (H.W., L.D., P.L.).ORCID 0000-0002-8887-4137
Philippe LambinClinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Department of Radiation Oncology (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.) and National Center for Tumor Diseases (NCT) (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.), Heidelberg University Hospital (UKHD), Heidelberg, Germany; German Cancer Consortium (DKTK) Core Center Heidelberg, Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., J.D., A.A., M.K.); National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.); Department of Clinical Pathology, Suez Canal University, Ismailia, Egypt (M.M.); Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z.); and The D-Laboratory and the M-Laboratory, Department of Precision Medicine, GROW-School for Oncology, Maastricht University, Maastricht, the Netherlands (H.W., L.D., P.L.).ORCID 0000-0001-7961-0191
Jürgen DebusClinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Department of Radiation Oncology (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.) and National Center for Tumor Diseases (NCT) (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.), Heidelberg University Hospital (UKHD), Heidelberg, Germany; German Cancer Consortium (DKTK) Core Center Heidelberg, Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., J.D., A.A., M.K.); National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.); Department of Clinical Pathology, Suez Canal University, Ismailia, Egypt (M.M.); Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z.); and The D-Laboratory and the M-Laboratory, Department of Precision Medicine, GROW-School for Oncology, Maastricht University, Maastricht, the Netherlands (H.W., L.D., P.L.).
Amir AbdollahiClinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Department of Radiation Oncology (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.) and National Center for Tumor Diseases (NCT) (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.), Heidelberg University Hospital (UKHD), Heidelberg, Germany; German Cancer Consortium (DKTK) Core Center Heidelberg, Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., J.D., A.A., M.K.); National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.); Department of Clinical Pathology, Suez Canal University, Ismailia, Egypt (M.M.); Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z.); and The D-Laboratory and the M-Laboratory, Department of Precision Medicine, GROW-School for Oncology, Maastricht University, Maastricht, the Netherlands (H.W., L.D., P.L.).
Maximilian KnollClinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Department of Radiation Oncology (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.) and National Center for Tumor Diseases (NCT) (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.), Heidelberg University Hospital (UKHD), Heidelberg, Germany; German Cancer Consortium (DKTK) Core Center Heidelberg, Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., J.D., A.A., M.K.); National Center for Radiation Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., A.K., J.D., A.A., M.K.); Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany (F.S., P.S., M.M., C.Z., C.S., K.R., N.B., J.D., A.A., M.K.); Department of Clinical Pathology, Suez Canal University, Ismailia, Egypt (M.M.); Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z.); and The D-Laboratory and the M-Laboratory, Department of Precision Medicine, GROW-School for Oncology, Maastricht University, Maastricht, the Netherlands (H.W., L.D., P.L.).ORCID 0000-0002-9037-3980
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To develop a model to accurately segment mouse lungs with varying levels of fibrosis and investigate its applicability to mouse images with different resolutions. Materials and Methods: In this experimental retrospective study, a U-Net was trained to automatically segment lungs on mouse CT images. The model was trained ( Results: The trained model yielded a high median DSC in both test datasets: 0.984 (interquartile range [IQR], 0.977-0.988) in group A and 0.966 (IQR, 0.955-0.972) in group B. The median HD in both test datasets was 0.47 mm (IQR, 0-0.51 mm [group A]) and 0.31 mm (IQR, 0.30-0.32 mm [group B]). Spatially resolved quantification of differences toward reference masks revealed two hot spots close to the air-tissue interfaces, which are particularly prone to deviation. Finally, for the higher-resolution mouse CT images, the median DSC was 0.905 (IQR, 0.902-0.929) and the median 95th percentile of the HD was 0.33 mm (IQR, 2.61-2.78 mm). Conclusion: The developed deep learning-based method for mouse lung segmentation performed well independently of disease state (healthy, fibrotic, emphysematous lungs) and CT resolution.
Indexed as
Animal StudiesCTDeep LearningLungLung FibrosisRadiation TherapySegmentationThorax
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