Evidence map›Paper›PMID 35390531›Full record

ArticlePractical radiation oncology

Longitudinal Changes in Bone Mineral Measurements Inside and Outside Radiation Fields Used for Cervical Cancer Treatment.

Juliana Wu, David S Lakomy, Bryan M Fellman, Mila P Salcedo, Anil K Sood, Anuja Jhingran, Ann H Klopp, Revathy B Iyer, Camilo Jimenez, Lauren E Colbert and 3 more

Abstract read
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In one paragraph

Article in Practical radiation oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. A prospective study of changes in bone health in adult cancer patients treated with pelvic radiotherapy.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2024
    Article
  3. Relative Effects of Radiation-Induced Changes in Bone Mass, Structure, and Tissue Material on Vertebral Strength in a Rat Model.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Juliana WuUniversity of Texas Medical Branch, Galveston, Texas; Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.
David S LakomyDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas; Dartmouth Geisel School of Medicine, Hanover, New Hampshire.
Bryan M FellmanDepartment of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas.
Mila P SalcedoDepartment of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas; Obstetrics and Gynecology Department, Federal University of Health Sciences/Irmandade Santa Casa de Misericordia, Porto Alegre, Brazil.
Anil K SoodDepartment of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas.
Anuja JhingranDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Ann H KloppDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Revathy B IyerDepartment of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Camilo JimenezDepartment of Endocrinology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Lauren E ColbertDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Patricia J EifelDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Kathleen M SchmelerDepartment of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas.
Lilie L LinDepartment of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address: LLLin@mdanderson.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe compared the magnitude of changes in bone mineral density (BMD), within and outside the radiation field, among women who received pelvic radiation therapy (RT) with or without chemotherapy for cervical cancer. METHODS AND MATERIALS: In this secondary analysis of a prospective study, we analyzed serial computed tomography scans and dual-energy x-ray absorptiometry scans from 78 patients who received definitive RT or chemoradiation therapy (CRT) for cervical cancer at a single institution from 2008 to 2015. BMD values at L1, L2, L3, and L4 were measured. We compared changes in BMD within the radiation field (ie, at L4) with those outside the field (ie, at L1). Linear mixed models were also used to examine the effect of RT on changes in BMD over time and covariate adjustment.

resultsThe median age of the 78 patients was 45.5 years (range, 23-88 years); all received RT and 76 (97%) received concurrent CRT. Treatment was associated with significant declines in BMD in all 4 lumbar vertebral bodies over time (P < .05), with nadir at 3 months for L4 and at 1 year for L1. Pairwise comparisons at 3 months and 2 years after treatment indicated that BMD in L4 (within the RT field) had improved (P = .037), but BMD in L1 (outside the RT field) was no different at 3 months and 2 years.

conclusionsSignificant BMD declines were observed in all lumbar vertebral bodies immediately after RT. However, in-field vertebral bodies reached nadir BMD earlier than those located outside the RT field. Our results suggest that treatment and patient-related factors other than RT may contribute to declines in BMD after treatment for cervical cancer. Routine bone density screening and post-RT therapy with hormones may be beneficial for selected patients who receive CRT for cervical cancer.

Indexed as

Uterine Cervical NeoplasmsAbsorptiometry, PhotonAdultAgedAged, 80 and overBone DensityFemaleHumansMiddle AgedMineralsProspective StudiesYoung AdultMinerals

Identifiers

PMID35390531

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.