Evidence map›Paper›PMID 35390299›Full record

ArticleEnvironmental research2022

Associations of prepubertal urinary phthalate metabolite concentrations with pubertal onset among a longitudinal cohort of boys.

Jane S Burns, Oleg Sergeyev, Mary M Lee, Paige L Williams, Lidia Mínguez-Alarcón, Bora Plaku-Alakbarova, Sergey Sokolov, Sergey Kovalev, Holger M Koch, Albert T Lebedev and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Article
  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Jane S BurnsEnvironmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Building 1, Boston, MA, 02115, USA. Electronic address: jburns@hsph.harvard.edu.
Oleg SergeyevGroup of Epigenetic Epidemiology, Belozersky Research Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskye Gory, House 1, Building 40, Room 322, 119992, Moscow, Russia; Chapaevsk Medical Association, Meditsinskaya Str., 3a, Chapaevsk, Samara Region, 446100, Russia.
Mary M LeeNemours Children's Health, 1600 Rockland Road, Wilmington, 19803, USA; Department of Pediatrics, Sidney Kimmel Medical School, Jefferson University, Philadelphia, PA, USA.
Paige L WilliamsDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Building 2, Room 443, Boston, MA, 02115, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave., Kresge Building, 9th Floor, Boston, MA, 02115, USA.
Lidia Mínguez-AlarcónEnvironmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Building 1, Boston, MA, 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 401 Park Drive, 3rd Floor West, Boston, MA, 02215, USA.
Bora Plaku-AlakbarovaEnvironmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Building 1, Boston, MA, 02115, USA; Epidemiology Division, Optuminsight Life Sciences, Boston, MA, USA.
Sergey SokolovChemistry Department, Lomonosov Moscow State University, Moscow, 119991, Leninskie Gory 1/3, Russian Federation.
Sergey KovalevChemistry Department, Lomonosov Moscow State University, Moscow, 119991, Leninskie Gory 1/3, Russian Federation.
Holger M KochInstitute for Prevention and Occupational Medicine of the German Social Accident Insurance - Institute of the Ruhr University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.
Albert T LebedevChemistry Department, Lomonosov Moscow State University, Moscow, 119991, Leninskie Gory 1/3, Russian Federation.
Russ HauserEnvironmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Building 1, Boston, MA, 02115, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave., Kresge Building, 9th Floor, Boston, MA, 02115, USA.
Susan A KorrickEnvironmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Building 1, Boston, MA, 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 401 Park Drive, 3rd Floor West, Boston, MA, 02215, USA.
Russian Children's Study
Harvard University · USLomonosov Moscow State University · RUBrigham and Women's Hospital · USInstitute for Prevention and Occupational Medicine · DEThomas Jefferson University · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Effects of Environmental Phthalates and Chemical Mixtures on Male Puberty and Semen QualityR01ES014370 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI HAUSER, RUSS B · 2006 to 2021
$8.2M
NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES014370
6 · The paper itself

Abstract

backgroundAlthough phthalate exposures have been associated with adverse effects on male reproductive health, few studies have explored longitudinal associations with male pubertal development.

objectivesWe examined the association of prepubertal urinary concentrations of phthalate metabolites with age at pubertal onset in a prospective cohort of Russian boys.

methodsAt enrollment at ages 8-9 years, medical history, dietary, and demographic information was collected. At entry and annually, physical examinations and pubertal staging [Genitalia (G), Pubarche (P), and testicular volume (TV, in ml)] were conducted and spot urines were collected. Prepubertal urine samples (defined as either TV = 1, 2 and G = 1, 2 or TV = 3 and G = 1) were pooled for each boy and phthalate metabolite concentrations were quantified using isotope dilution LC-MS/MS at Moscow State University. We measured 15 metabolites including those from anti-androgenic parent phthalates (AAPs) such as di (2-ethylhexyl) (DEHP) and di-isononyl (DiNP) phthalates as well as monobenzyl (MBzP), mono-n-butyl (MnBP), and mono-isobutyl (MiBP) metabolites. We calculated the molar sums of DEHP (∑DEHP), DiNP (∑DiNP), and AAP (∑AAP) metabolites. Separate interval-censored models were used to assess associations of quartiles of prepubertal phthalate metabolites with each pubertal onset indicator, G2+, P2+ and TV > 3 mL, adjusted for covariates and urine specific gravity.

results304 boys had 752 prepubertal urine samples (median 2, range: 1-6) for pooling. In adjusted models, higher urinary AAPs were consistently associated with later pubertal onset (P2) with mean shifts ranging from 8.4 to 14.2 months for the highest versus lowest quartiles. Significantly later onset for G2 and TV > 3 mL was observed for higher versus lower quartiles of MiBP, MBzP, ∑DEHP and ∑DiNP.

conclusionsOn average, boys with higher concentrations of prepubertal urinary AAPs had later pubertal onset by six months to over a year. The impact of AAPs on timing of male puberty may be attributable to disruption of androgen-dependent biological pathways.

Indexed as

Diethylhexyl PhthalateEnvironmental PollutantsPhthalic AcidsAndrogen AntagonistsChildChromatography, LiquidEnvironmental ExposureHumansMaleProspective StudiesTandem Mass SpectrometryAndrogen AntagonistsDiethylhexyl PhthalateEnvironmental Pollutantsphthalic acidPhthalic AcidsChildrenEndocrine disrupting chemicalsEnvironmentPhthalatesPubertyTanner staging

Identifiers

PMID35390299
PMCPMC9310051
OpenAlexW4223445196

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.