Evidence map›Paper›PMID 35390280›Full record

ArticleCurrent biology : CB2022

Enhanced lipogenesis through Pparγ helps cavefish adapt to food scarcity.

Shaolei Xiong, Wei Wang, Alexander Kenzior, Luke Olsen, Jaya Krishnan, Jenna Persons, Kyle Medley, Robert Peuß, Yongfu Wang, Shiyuan Chen and 5 more

Open access · greenAbstract read
In one paragraph

Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
36.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 62 citations in OpenAlex.

  1. Review
  2. Article
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  5. Automated Profiling of Social Behaviors to Assess the Genetic Basis of Evolution of Aggressive Behaviors in Astyanax mexicanus.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026
    Article
  6. Article
  7. Novel mechanisms of chemosensory adaptation to the cave environment.bioRxiv : the preprint server for biology · 2026
    Article
  8. Article
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  14. Divergent 3D genome organization in livers of cave and surface morphs ofbioRxiv : the preprint server for biology · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. A complex mechanism translating variation of a simple genetic architecture into alternative life histories.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 3 countries.

Shaolei XiongStowers Institute for Medical Research, Kansas City, MO 64110, USA.
Wei WangStowers Institute for Medical Research, Kansas City, MO 64110, USA; Howard Hughes Medical Institute, Kansas City, MO 64110, USA; National Institute of Biological Sciences, Beijing 102206, China.
Alexander KenziorStowers Institute for Medical Research, Kansas City, MO 64110, USA.
Luke OlsenStowers Institute for Medical Research, Kansas City, MO 64110, USA; Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Jaya KrishnanStowers Institute for Medical Research, Kansas City, MO 64110, USA.
Jenna PersonsStowers Institute for Medical Research, Kansas City, MO 64110, USA.
Kyle MedleyStowers Institute for Medical Research, Kansas City, MO 64110, USA.
Robert PeußStowers Institute for Medical Research, Kansas City, MO 64110, USA; Institute for Evolution and Biodiversity, University of Münster, Münster 48149, Germany.
Yongfu WangStowers Institute for Medical Research, Kansas City, MO 64110, USA.
Shiyuan ChenStowers Institute for Medical Research, Kansas City, MO 64110, USA.
Ning ZhangStowers Institute for Medical Research, Kansas City, MO 64110, USA.
Nancy ThomasStowers Institute for Medical Research, Kansas City, MO 64110, USA.
John M MilesDepartment of Medicine, Division of Metabolism, Endocrinology & Genetics, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Alejandro Sánchez AlvaradoStowers Institute for Medical Research, Kansas City, MO 64110, USA; Howard Hughes Medical Institute, Kansas City, MO 64110, USA.
Nicolas RohnerStowers Institute for Medical Research, Kansas City, MO 64110, USA; Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA. Electronic address: nro@stowers.org.
Stowers Institute for Medical Research · USUniversity of Kansas Medical Center · US

Funding

A genomic toolkit for functional interrogation of trait variation in an aquatic modelR24OD030214 · OD · UNIVERSITY OF MISSOURI-COLUMBIA · PI KEENE, ALEX C, WARREN, WESLEY CHARLES · 2022 to 2025
$2.8M
Starvation resistance and resilience of metabolic dysfunction in cavefishDP2AG071466 · NIA · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI ROHNER, NICOLAS · 2020 to 2020
$2.5M
Understanding complex trait architecture through population genomicsR01GM127872 · NIGMS · UNIVERSITY OF MINNESOTA · PI KEENE, ALEX C, MCGAUGH, SUZANNE · 2018 to 2021
$1.7M
NIA NIH HHS DP2 AG071466NIGMS NIH HHS R01 GM127872NIH HHS R24 OD030214
6 · The paper itself

Abstract

Nutrient availability varies seasonally and spatially in the wild. While many animals, such as hibernating animals or migrating birds, evolved strategies to overcome periods of nutrient scarcity,

Indexed as

CharacidaePPAR gammaAdaptation, PhysiologicalAnimalsBiological EvolutionCavesLipogenesisPPAR gammaadaptationAstyanax mexicanuscavefishfat storagelipid metabolismlipogenesisper2pparγ

Identifiers

PMID35390280
PMCPMC9133166
OpenAlexW4224261336

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.