ArticleJournal of the American Chemical Society2022
Assembly of π-Stacking Helical Peptides into a Porous and Multivariable Proteomimetic Framework.
Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Free-standing ultrathin two-dimensional peptide crystals.Nature chemistry · 2026Article
- Nanographene-Based van der Waals Organic Framework With Permanent Porosity.Angewandte Chemie (International ed. in English) · 2026Article
- Mesoporous peptide frameworks engineered from crystallizable collagen-mimetic peptide amphiphiles.Nature communications · 2026Article
- Article
- Peptide cages: bioinspired supramolecular architectures for next-generation applications.Chemical science · 2026Review
- Emergent properties of supramolecular peptide assemblies.Chemical communications (Cambridge, England) · 2026Review
- Assembly of dynamic helical β-peptides with switchable handedness into multiple types of metal-peptide frameworks.Nature communications · 2025Article
- Discrete Actuation of Water-Responsive Crystalline Metal-Peptide Frameworks.Angewandte Chemie (International ed. in English) · 2025Article
- An α-Helically Folded α-Aminoisobutyric Acid (Aib) Oligomer That Assembles into a Metal-Peptide Superhelical Nanotube.Journal of the American Chemical Society · 2025Article
- Metal-α-Helix Peptide Frameworks.Journal of the American Chemical Society · 2025Article
- Chemical methods to stabilize segments of metalloproteins in the form of peptides.Methods in enzymology · 2025Article
- Bottom-up construction of chiral metal-peptide assemblies from metal cluster motifs.Nature communications · 2024Article
- Structural Characterization of Disulfide-Linked p53-Derived Peptide Dimers.Research square · 2024Article
- Article
- Noncovalent Peptide Assembly Enables Crystalline, Permutable, and Reactive Thiol Frameworks.Journal of the American Chemical Society · 2023Article
- Effector-dependent structural transformation of a crystalline framework with allosteric effects on molecular recognition ability.Nature communications · 2023Article
- Peptide-derived coordination frameworks for biomimetic and selective separation.Analytical and bioanalytical chemistry · 2023Review
- Influence of Lipidation Pattern of the KR12 Fragment of Peptide LL-37 on Its Antibacterial and Hemolytic Activities.International journal of molecular sciences · 2023Article
- Directing the Self-Assembly of Aromatic Foldamer Helices using Acridine Appendages and Metal Coordination.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Surfactant-Assisted Assembly of Dipeptide Forming a Broom-like Structure.Molecules (Basel, Switzerland) · 2022Article
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9 authors.
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Abstract
The evolution of proteins from simpler, self-assembled peptides provides a powerful blueprint for the design of complex synthetic materials. Previously, peptide-metal frameworks using short sequences (≤3 residues) have shown great promise as proteomimetic materials that exhibit sophisticated capabilities. However, their development has been hindered due to few variable residues and restricted choice of side-chains that are compatible with metal ions. Herein, we developed a noncovalent strategy featuring π-stacking bipyridyl residues to assemble much longer peptides into crystalline frameworks that tolerate even previously incompatible acidic and basic functionalities and allow an unprecedented level of pore variations. Single-crystal X-ray structures are provided for all variants to guide and validate rational design. These materials exhibit hallmark proteomimetic behaviors such as guest-selective induced fit and assembly of multimetallic units. Significantly, we demonstrate facile optimization of the framework design to substantially increase affinity toward a complex organic molecule.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.