Evidence map›Paper›PMID 35390209›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2022

Combinatorial Polyacrylamide Hydrogels for Preventing Biofouling on Implantable Biosensors.

Doreen Chan, Jun-Chau Chien, Eneko Axpe, Louis Blankemeier, Samuel W Baker, Sarath Swaminathan, Victoria A Piunova, Dmitry Yu Zubarev, Caitlin L Maikawa, Abigail K Grosskopf and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 177 citations in OpenAlex.

  1. Review
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  6. Strategies for Multiplexing Plasmonic Biosensing.Sensors (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Doreen ChanDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Jun-Chau ChienDepartment of Electrical Engineering, Stanford University, Stanford, CA, 94305, USA.
Eneko AxpeDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, 94305, USA.
Louis BlankemeierDepartment of Electrical Engineering, Stanford University, Stanford, CA, 94305, USA.
Samuel W BakerDepartment of Comparative Medicine, Stanford University, Stanford, CA, 94305, USA.
Sarath SwaminathanIBM Almaden Research Center, San Jose, CA, 95120, USA.
Victoria A PiunovaIBM Almaden Research Center, San Jose, CA, 95120, USA.
Dmitry Yu ZubarevIBM Almaden Research Center, San Jose, CA, 95120, USA.
Caitlin L MaikawaDepartment of Bioengineering, Stanford University, Stanford, CA, 94305, USA.
Abigail K GrosskopfDepartment of Chemical Engineering, Stanford University, Stanford, CA, 94305, USA.
Joseph L MannDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, 94305, USA.
H Tom SohDepartment of Electrical Engineering, Stanford University, Stanford, CA, 94305, USA.
Eric A AppelDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, 94305, USA.ORCID https://orcid.org/0000-0002-2301-7126
Stanford University · USIBM Research - Almaden · USCardiovascular Institute of the South · US

Funding

Co-Formulations of Amylin Analogues with Insulin Analogues for Treatment of DiabetesR01DK119254 · NIDDK · STANFORD UNIVERSITY · PI APPEL, ERIC ANDREW · 2019 to 2023
$2.9M
2016 SETAC Asia/Pacific ConferenceR13ES027302 · NIEHS · SOCIETY/ENVIRONMENTAL TOXICOLOGY/CHEM · PI MENZIE, CHARLES · 2016 to 2016
$6k
Air Force Office of Scientific ResearchDepartment of DefenseEuropean Union's Horizon 2020 796557National Defense Science and Engineering Graduate FA9550-11-C-0028National Science Foundation ECCS-1542152NIDDK NIH HHS R01 DK119254NIDDK NIH HHS R01DK119254NIEHS NIH HHS 27302C0028Stanford Bio-X Interdisciplinary Initiative Program RoundStanford Nano Shared Facilities
6 · The paper itself

Abstract

Biofouling on the surface of implanted medical devices and biosensors severely hinders device functionality and drastically shortens device lifetime. Poly(ethylene glycol) and zwitterionic polymers are currently considered "gold-standard" device coatings to reduce biofouling. To discover novel anti-biofouling materials, a combinatorial library of polyacrylamide-based copolymer hydrogels is created, and their ability is screened to prevent fouling from serum and platelet-rich plasma in a high-throughput parallel assay. It is found that certain nonintuitive copolymer compositions exhibit superior anti-biofouling properties over current gold-standard materials, and machine learning is used to identify key molecular features underpinning their performance. For validation, the surfaces of electrochemical biosensors are coated with hydrogels and their anti-biofouling performance in vitro and in vivo in rodent models is evaluated. The copolymer hydrogels preserve device function and enable continuous measurements of a small-molecule drug in vivo better than gold-standard coatings. The novel methodology described enables the discovery of anti-biofouling materials that can extend the lifetime of real-time in vivo sensing devices.

Indexed as

BiofoulingBiosensing TechniquesAcrylic ResinsHydrogelsPolymersProstheses and ImplantsSurface PropertiesAcrylic ResinsHydrogelspolyacrylamide gelsPolymersantifoulingbiosensorshydrogelsimplanted devicespolyacrylamide

Identifiers

PMID35390209
PMCPMC9793805
OpenAlexW4226151042

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.