ArticleMedical physics2022
High-resolution and high-sensitivity PET for quantitative molecular imaging of the monoaminergic nuclei: A GATE simulation study.
Article in Medical physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 21 citations in OpenAlex.
- Inter-crystal scatter recovery of a light-sharing depth-encoding Prism-PET prototype scanner using a diffusion model.Medical physics · 2026Article
- Eagle eyes on the human brain and beyond: PET at ultra-high spatial resolution.European journal of nuclear medicine and molecular imaging · 2026Article
- Optimizing positron emission tomography for accurate plant imaging using Monte Carlo simulations to correct positron range effects.Scientific reports · 2025Article
- High-resolution motion compensation for brain PET imaging using real-time electromagnetic motion tracking.Medical physics · 2025Article
- Depth-encoding using optical photon TOF in a prism-PET detector with tapered crystals.Medical physics · 2024Article
- Resolving inter-crystal scatter in a light-sharing depth-encoding PET detector.Physics in medicine and biology · 2024Article
- Performance evaluation of the PennPET explorer with expanded axial coverage.Physics in medicine and biology · 2023Article
- A conformal TOF-DOI Prism-PET prototype scanner for high-resolution quantitative neuroimaging.Medical physics · 2023Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
purposeQuantitative in vivo molecular imaging of fine brain structures requires high-spatial resolution and high-sensitivity. Positron emission tomography (PET) is an attractive candidate to introduce molecular imaging into standard clinical care due to its highly targeted and versatile imaging capabilities based on the radiotracer being used. However, PET suffers from relatively poor spatial resolution compared to other clinical imaging modalities, which limits its ability to accurately quantify radiotracer uptake in brain regions and nuclei smaller than 3 mm in diameter. Here we introduce a new practical and cost-effective high-resolution and high-sensitivity brain-dedicated PET scanner, using our depth-encoding Prism-PET detector modules arranged in a conformal decagon geometry, to substantially reduce the partial volume effect and enable accurate radiotracer uptake quantification in small subcortical nuclei.
methodsTwo Prism-PET brain scanner setups were proposed based on our 4-to-1 and 9-to-1 coupling of scintillators to readout pixels using
resultsThe Prism-PET brain scanner with 1.5 mm crystals is superior to that with 1 mm crystals as the former offers better depth-of-interaction (DOI) resolution, which is key to realizing compact and conformal PET scanner geometries. We achieved uniform 1.3 mm full-width-at-half-maximum (FWHM) spatial resolutions across the entire transaxial field-of-view (FOV), a NEMA sensitivity of 52.1 kcps/MBq, and a peak noise equivalent count rate (NECR) of 957.8 kcps at 25.2 kBq/mL using 450-650 keV energy window. Hot spot phantom results demonstrate that our scanner can resolve regions as small as 1.35 mm in diameter at both center and 10 cm away from the center of the transaixal FOV. Both 5-HT
conclusionsBased on our simulation results, the proposed high-resolution and high-sensitivity Prism-PET brain scanner is a promising cost-effective candidate to achieve quantitative molecular neuroimaging of small but important brain regions with PET clinically viable.
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