SynthesisPloS one2022
Depression and unplanned secondary healthcare use in patients with multimorbidity: A systematic review.
Synthesis in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Natural Language Response Formats for Assessing Depression and Worry With Large Language Models: A Sequential Evaluation With Model Pre-Registration.Assessment · 2026Article
- Comparative effectiveness of antidepressants for depression using EHRs from two health systems.BMC psychiatry · 2026Article
- A Study on the Bidirectional Effects of Depression and Household Savings: Empirical Evidence from CHARLS.Healthcare (Basel, Switzerland) · 2026Article
- Depression and Multimorbidity among Older Indians Residing in Front-Runner, Achiever and Aspirant States: Insight from Longitudinal Ageing Study in India (LASI) - Wave I.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2026Article
- Optimal dose and pattern of physical activity to prevent diagnosed depression: prospective cohort study.Psychological medicine · 2025Article
- Article
- Multimorbidity-associated emergency hospital admissions: a "screen and link" strategy to improve outcomes for high-risk patients in sub-Saharan Africa: a prospective multicentre cohort study protocol.NIHR open research · 2024Article
- Continuity of care in diverse ethnic groups: a general practice record study in England.The British journal of general practice : the journal of the Royal College of General Practitioners · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundGrowing numbers of people with multimorbidity have a co-occurring mental health condition such as depression. Co-occurring depression is associated with poor patient outcomes and increased healthcare costs including unplanned use of secondary healthcare which may be avoidable.
aimTo summarise the current evidence on the association between depression and unplanned secondary healthcare use among patients with multimorbidity.
methodsWe conducted a systematic review by searching MEDLINE, EMBASE, PsychINFO, Web of Science, CINAHL, and Cochrane Library from January 2000 to March 2021. We included studies on adults with depression and at least one other physical long-term condition that examined risk of emergency hospital admissions as a primary outcome, alongside emergency department visits or emergency readmissions. Studies were assessed for risk of bias using The National Institute of Health National Heart, Lung, and Blood Institute quality assessment tool. Relevant data were extracted from studies and a narrative synthesis of findings produced.
resultsTwenty observational studies were included in the review. Depression was significantly associated with different outcomes of unplanned secondary healthcare use, across various comorbidities. Among the studies examining these outcomes, depression predicted emergency department visits in 7 out of 9 studies; emergency hospital admissions in 19 out of 20 studies; and emergency readmissions in 4 out of 4 studies. This effect increased with greater severity of depression. Other predictors of unplanned secondary care reported include increased age, being female, and presence of greater numbers of comorbidities.
conclusionDepression predicted increased risk of unplanned secondary healthcare use in individuals with multimorbidity. The literature indicates a research gap in identifying and understanding the impact of complex multimorbidity combinations, and other patient characteristics on unplanned care in patients with depression. Findings indicate the need to improve planned care for patients with moderate-to-severe depression. We suggest regular reviews of care plans, depression severity monitoring and assessment of hospital admission risk in primary care settings.
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