Evidence map›Paper›PMID 35390012›Full record

ArticlePloS one2022

Chronic kidney disease and atrial fibrillation: A dangerous combination.

Gurbey Ocak, Meriem Khairoun, Othman Khairoun, Willem Jan W Bos, Edouard L Fu, Maarten J Cramer, Jan Westerink, Marianne C Verhaar, Frank L Visseren, UCC-SMART study group

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

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  20. ANMCO-SIMEU consensus document: appropriate management of atrial fibrillation in the emergency department.European heart journal supplements : journal of the European Society of Cardiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Gurbey OcakDepartment of Internal Medicine, Sint Antonius Hospital, Nieuwegein, the Netherlands.ORCID 0000-0003-4288-7685
Meriem KhairounDepartment of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, the Netherlands.
Othman KhairounDepartment of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, the Netherlands.
Willem Jan W BosDepartment of Internal Medicine, Sint Antonius Hospital, Nieuwegein, the Netherlands.
Edouard L FuDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Maarten J CramerDepartment of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Jan WesterinkDepartment of Vascular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
Marianne C VerhaarDepartment of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, the Netherlands.
Frank L VisserenDepartment of Vascular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
UCC-SMART study group
University Medical Center Utrecht · NLLeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic kidney disease (CKD) and atrial fibrillation (AF) are both risk factors for bleeding, stroke and mortality. The aim of our study was to investigate the interaction between CKD and atrial fibrillation and outcomes.

methodsWe included 12,394 subjects referred to the University Medical Center Utrecht (the Netherlands) from September 1996 to February 2018 for an out-patient visit (Utrecht Cardiovascular Cohort Second Manifestation of Arterial disease cohort). Hazard ratios (HRs) with 95% confidence intervals (CIs) for bleeding, ischemic stroke or mortality were calculated with Cox proportional hazard analyses. Presence of interaction between AF and CKD was examined by calculating the relative excess risk due to interaction (RERI), the attributable proportion (AP) due to interaction and the synergy index (S).

resultsOf the 12,394 patients, 699 patients had AF, 2,752 patients had CKD and 325 patients had both AF and CKD. Patients with both CKD and AF had a 3.0-fold (95% CI 2.0-4.4) increased risk for bleeding, a 4.2-fold (95% CI 3.0-6.0) increased ischemic stroke risk and a 2.2-fold (95% CI 1.9-2.6) increased mortality risk after adjustment as compared with subjects without atrial fibrillation and CKD. We did not find interaction between AF and CKD for bleeding and mortality. However, we found interaction between AF and CKD for ischemic stroke risk (RERI 1.88 (95% CI 0.31-3.46), AP 0.45 (95% CI 0.17-0.72) and S 2.40 (95% CI 1.08-5.32)).

conclusionAF and CKD are both associated with bleeding, ischemic stroke and mortality. There is a positive interaction between AF and CKD for ischemic stroke risk, but not for bleeding or mortality.

Indexed as

Atrial FibrillationIschemic StrokeRenal Insufficiency, ChronicStrokeAnticoagulantsHemorrhageHumansRisk FactorsAnticoagulants

Identifiers

PMID35390012
PMCPMC8989340
OpenAlexW4226377825

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.