Evidence map›Paper›PMID 35389828›Full record

ArticleBioengineered2022

HLA complex P5 upregulation is correlated with poor prognosis and tumor progression in esophageal squamous cell carcinoma.

Yaqin Wang, Zhijun Yu, Weidong Shi, Jian Shen, Yun Guan, Feng Ni

Open access · goldAbstract read
In one paragraph

Article in Bioengineered, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. mFrontiers in cell and developmental biology · 2026
    Review
  3. mActa pharmaceutica Sinica. B · 2025
    Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. YTHDF1 in Tumor Cell Metabolism: An Updated Review.Molecules (Basel, Switzerland) · 2023
    Review
  9. Novel insights into mutual regulation between NCancer cell international · 2023
    Review
  10. The diverse role of RNA methylation in esophageal cancer.Acta biochimica et biophysica Sinica · 2023
    Review
  11. Review
  12. Review
  13. Article
  14. The roles of RNA NHeliyon · 2022
    Review
  15. The Role of mCancers · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yaqin WangDepartment of Thoracic Surgery, The Affiliated Huai'an Hospital of Xuzhou Medical University&The Second People's Hospital of Huai'an, Huai'an, Jiangsu Province, China.
Zhijun YuDepartment of Thoracic Surgery, Nantong Second People's Hospital, Nantong, Jiangsu Province, China.
Weidong ShiDepartment of Thoracic Surgery, Nantong Second People's Hospital, Nantong, Jiangsu Province, China.
Jian ShenDepartment of Radiotherapy, Nantong University Affiliated Cancer Hospital, Nantong, Jiangsu Province, China.
Yun GuanDepartment of Radiotherapy, Nantong University Affiliated Cancer Hospital, Nantong, Jiangsu Province, China.
Feng NiDepartment of Radiotherapy, Nantong University Affiliated Cancer Hospital, Nantong, Jiangsu Province, China.ORCID 0000-0003-1674-8315
Nantong University · CNXuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Esophageal squamous cell carcinoma (ESCC) is a deadly malignant tumor that threatens human health. Long noncoding RNA (lncRNA) is widely expressed in eukaryotes and is closely associated with human disease progression. However, its role in ESCC remains incompletely understood. In this study, we analyzed the results of three gene expression omnibus (GEO) databases containing lncRNA expression data of ESCC and normal tissues. The results showed that HCP5 was significantly overexpressed in ESCC tissues, which was further verified in our collected ESCC samples. The functional study suggested that HCP5 knockdown inhibited ESCC cell proliferation and invasion. Regarding the mechanism, HCP5 was able to directly interact with YTHDF1, a N6-methyladenosine (m

Indexed as

Esophageal NeoplasmsEsophageal Squamous Cell CarcinomaRNA, Long NoncodingAnimalsCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansMiceMice, NudePrognosisUp-RegulationHCP5 long noncoding RNA, humanRNA, Long NoncodingbiomarkerESCCHCP5m6Awarburg effect

Identifiers

PMID35389828
PMCPMC9208456
OpenAlexW4225884129

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.