Evidence map›Paper›PMID 35389756›Full record

ArticleCirculation2022

Skeletal Muscle Disorders: A Noncardiac Source of Cardiac Troponin T.

Jeanne du Fay de Lavallaz, Alexandra Prepoudis, Maria Janina Wendebourg, Eva Kesenheimer, Diego Kyburz, Thomas Daikeler, Philip Haaf, Julia Wanschitz, Wolfgang N Löscher, Bettina Schreiner and 21 more

Registry-linked trialOpen access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03660969 (Heart&Muscle Study), which is not on this map. Cited by 66 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 1 pooled it
17.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03660969 active not recruitingnot on this map

Heart&Muscle Study

TypeobservationalSponsorUniversity Hospital, Basel, SwitzerlandRan2018 to 2028Enrolled797ConditionsMyopathy, Muscle Weakness, Muscle Damage, Muscle Spasticity
3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.

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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors at 6 institutions in 3 countries.

Jeanne du Fay de Lavallaz *Cardiovascular Research Institute Basel (J.d.F.d.L., A.P., P.H., D.M.G., A.A., C.P., J.B., T.N., P.L.-A., N.G., S.S., S.P., J. Gallon, S.W., C.M.), University Hospital of Basel, Switzerland.ORCID 0000-0002-0806-1786
Alexandra Prepoudis *Cardiovascular Research Institute Basel (J.d.F.d.L., A.P., P.H., D.M.G., A.A., C.P., J.B., T.N., P.L.-A., N.G., S.S., S.P., J. Gallon, S.W., C.M.), University Hospital of Basel, Switzerland.ORCID 0000-0001-5777-0418
Maria Janina WendebourgNeurology Clinic and Policlinic (M.J.W., E.K., M.S.), University Hospital of Basel, Switzerland.ORCID 0000-0003-4812-8807
Eva KesenheimerNeurology Clinic and Policlinic (M.J.W., E.K., M.S.), University Hospital of Basel, Switzerland.
Diego KyburzDepartment of Rheumatology (D.K., T.D.), University Hospital of Basel, Switzerland.
Thomas DaikelerDepartment of Rheumatology (D.K., T.D.), University Hospital of Basel, Switzerland.
Philip HaafCardiovascular Research Institute Basel (J.d.F.d.L., A.P., P.H., D.M.G., A.A., C.P., J.B., T.N., P.L.-A., N.G., S.S., S.P., J. Gallon, S.W., C.M.), University Hospital of Basel, Switzerland.ORCID 0000-0002-5657-6637
Julia WanschitzDepartments of Neurology (J.W., W.N.L.), Medical University of Innsbruck, Austria.
Wolfgang N LöscherDepartments of Neurology (J.W., W.N.L.), Medical University of Innsbruck, Austria.
Bettina SchreinerDepartments of Neurology (B.S., M.K., H.H.J.), University Hospital of Zürich, Switzerland.
Mira KatanDepartments of Neurology (B.S., M.K., H.H.J.), University Hospital of Zürich, Switzerland.ORCID 0000-0002-9265-8066
Hans H JungDepartments of Neurology (B.S., M.K., H.H.J.), University Hospital of Zürich, Switzerland.
Britta MaurerRheumatology (B.M.), University Hospital of Zürich, Switzerland.
Angelika Hammerer-LercherDepartment of Laboratory Medicine, Cantonal Hospital of Aarau, Switzerland (A.H.-L.).
Agnes MayrRadiology (A.M.), Medical University of Innsbruck, Austria.ORCID 0000-0001-9363-873X
Danielle M GualandroCardiovascular Research Institute Basel (J.d.F.d.L., A.P., P.H., D.M.G., A.A., C.P., J.B., T.N., P.L.-A., N.G., S.S., S.P., J. Gallon, S.W., C.M.), University Hospital of Basel, Switzerland.
Annemarie AcketCardiovascular Research Institute Basel (J.d.F.d.L., A.P., P.H., D.M.G., A.A., C.P., J.B., T.N., P.L.-A., N.G., S.S., S.P., J. Gallon, S.W., C.M.), University Hospital of Basel, Switzerland.
Christian PuelacherCardiovascular Research Institute Basel (J.d.F.d.L., A.P., P.H., D.M.G., A.A., C.P., J.B., T.N., P.L.-A., N.G., S.S., S.P., J. Gallon, S.W., C.M.), University Hospital of Basel, Switzerland.
Jasper BoeddinghausCardiovascular Research Institute Basel (J.d.F.d.L., A.P., P.H., D.M.G., A.A., C.P., J.B., T.N., P.L.-A., N.G., S.S., S.P., J. Gallon, S.W., C.M.), University Hospital of Basel, Switzerland.ORCID 0000-0003-4404-4956
Thomas NestelbergerCardiovascular Research Institute Basel (J.d.F.d.L., A.P., P.H., D.M.G., A.A., C.P., J.B., T.N., P.L.-A., N.G., S.S., S.P., J. Gallon, S.W., C.M.), University Hospital of Basel, Switzerland.ORCID 0000-0003-2173-5738
Pedro Lopez-AyalaCardiovascular Research Institute Basel (J.d.F.d.L., A.P., P.H., D.M.G., A.A., C.P., J.B., T.N., P.L.-A., N.G., S.S., S.P., J. Gallon, S.W., C.M.), University Hospital of Basel, Switzerland.ORCID 0000-0002-7787-0640
Noemi GlarnerCardiovascular Research Institute Basel (J.d.F.d.L., A.P., P.H., D.M.G., A.A., C.P., J.B., T.N., P.L.-A., N.G., S.S., S.P., J. Gallon, S.W., C.M.), University Hospital of Basel, Switzerland.ORCID 0000-0001-9651-8848
Samyut ShresthaCardiovascular Research Institute Basel (J.d.F.d.L., A.P., P.H., D.M.G., A.A., C.P., J.B., T.N., P.L.-A., N.G., S.S., S.P., J. Gallon, S.W., C.M.), University Hospital of Basel, Switzerland.
Robert MankaCardiology (R.M.), University Hospital of Zürich, Switzerland.
Joanna GawineckaInstitute of Clinical Chemistry (J. Gawinecka), University Hospital of Zürich, Switzerland.
Salvatore PiscuoglioCardiovascular Research Institute Basel (J.d.F.d.L., A.P., P.H., D.M.G., A.A., C.P., J.B., T.N., P.L.-A., N.G., S.S., S.P., J. Gallon, S.W., C.M.), University Hospital of Basel, Switzerland.ORCID 0000-0003-2686-2939
John GallonCardiovascular Research Institute Basel (J.d.F.d.L., A.P., P.H., D.M.G., A.A., C.P., J.B., T.N., P.L.-A., N.G., S.S., S.P., J. Gallon, S.W., C.M.), University Hospital of Basel, Switzerland.
Sophia WiedemannCardiovascular Research Institute Basel (J.d.F.d.L., A.P., P.H., D.M.G., A.A., C.P., J.B., T.N., P.L.-A., N.G., S.S., S.P., J. Gallon, S.W., C.M.), University Hospital of Basel, Switzerland.ORCID 0000-0002-2632-6952
Michael SinnreichNeurology Clinic and Policlinic (M.J.W., E.K., M.S.), University Hospital of Basel, Switzerland.
Christian MuellerCardiovascular Research Institute Basel (J.d.F.d.L., A.P., P.H., D.M.G., A.A., C.P., J.B., T.N., P.L.-A., N.G., S.S., S.P., J. Gallon, S.W., C.M.), University Hospital of Basel, Switzerland.ORCID 0000-0002-1120-6405
BASEL XII Investigators
University Hospital of Basel · CHUniversity Hospital of Zurich · CHInnsbruck Medical University · ATUniversity of Basel · CHKantonsspital Aarau · CHUniversity Hospital of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiac troponin (cTn) T and cTnI are considered cardiac specific and equivalent in the diagnosis of acute myocardial infarction. Previous studies suggested rare skeletal myopathies as a noncardiac source of cTnT. We aimed to confirm the reliability/cardiac specificity of cTnT in patients with various skeletal muscle disorders (SMDs).

methodsWe prospectively enrolled patients presenting with muscular complaints (≥2 weeks) for elective evaluation in 4 hospitals in 2 countries. After a cardiac workup, patients were adjudicated into 3 predefined cardiac disease categories. Concentrations of cTnT/I and resulting cTnT/I mismatches were assessed with high-sensitivity (hs-) cTnT (hs-cTnT-Elecsys) and 3 hs-cTnI assays (hs-cTnI-Architect, hs-cTnI-Access, hs-cTnI-Vista) and compared with those of control subjects without SMD presenting with adjudicated noncardiac chest pain to the emergency department (n=3508; mean age, 55 years; 37% female). In patients with available skeletal muscle biopsies,

resultsAmong 211 patients (mean age, 57 years; 42% female), 108 (51%) were adjudicated to having no cardiac disease, 44 (21%) to having mild disease, and 59 (28%) to having severe cardiac disease. hs-cTnT/I concentrations significantly increased from patients with no to those with mild and severe cardiac disease for all assays (all

conclusionsIn patients with active chronic SMD, elevations in cTnT concentrations are common and not attributable to cardiac disease in the majority. This was not observed for cTnI and may be explained in part by re-expression of cTnT in skeletal muscle. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NCT03660969.

Indexed as

BiomarkersCase-Control StudiesFemaleHeart DiseasesHumansMaleMiddle AgedMuscular DiseasesProspective StudiesReproducibility of ResultsRNA, MessengerTroponin ITroponin TBiomarkersRNA, MessengerTroponin ITroponin Tmuscle, skeletalmyocardial infarctionmyopathies, structural, congenitaltroponin

Identifiers

PMID35389756
PMCPMC10069758
OpenAlexW4225736913

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.