Evidence map›Paper›PMID 35389515›Full record

ArticleEuropean journal of immunology2022

SARS-CoV-2-specific T cells are generated in less than half of allogeneic HSCT recipients failing to seroconvert after COVID-19 vaccination.

Andrea Jarisch, Eliza Wiercinska, Shabnam Daqiq-Mirdad, Helen Hellstern, Salem Ajib, Anjali Cremer, Ngoc Thien Thu Nguyen, Alexandra Dukat, Evelyn Ullrich, Sandra Ciesek and 6 more

Abstract read
In one paragraph

Article in European journal of immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. COVID-19 and HSCT (Hematopoietic stem cell transplant).Best practice & research. Clinical haematology · 2022
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Andrea JarischDivision of Pediatric Stem Cell Transplantation and Immunology, Goethe University, Frankfurt, Germany.ORCID 0000-0003-1639-2697
Eliza WiercinskaGerman Red Cross Blood Service BaWüHe, Frankfurt, Germany.
Shabnam Daqiq-MirdadGerman Red Cross Blood Service BaWüHe, Frankfurt, Germany.
Helen HellsternGerman Red Cross Blood Service BaWüHe, Frankfurt, Germany.
Salem AjibDepartment of Medicine, Hematology/Oncology, Goethe University, Frankfurt, Germany.
Anjali CremerDepartment of Medicine, Hematology/Oncology, Goethe University, Frankfurt, Germany.
Ngoc Thien Thu NguyenDepartment of Medicine, Hematology/Oncology, Goethe University, Frankfurt, Germany.
Alexandra DukatOutpatient Cancer Clinic AKS Schaubstraße, Frankfurt, Germany.
Evelyn UllrichDivision of Pediatric Stem Cell Transplantation and Immunology, Goethe University, Frankfurt, Germany.
Sandra CiesekInstitute for Medical Virology, Goethe University, Frankfurt, Germany.
Kai-Uwe ChowFrankfurt Cancer Institute (FCI), Goethe University, Frankfurt, Germany.
Hubert ServeDepartment of Medicine, Hematology/Oncology, Goethe University, Frankfurt, Germany.
Erhard SeifriedGerman Red Cross Blood Service BaWüHe, Frankfurt, Germany.
Peter BaderDivision of Pediatric Stem Cell Transplantation and Immunology, Goethe University, Frankfurt, Germany.
Halvard BonigGerman Red Cross Blood Service BaWüHe, Frankfurt, Germany.
Gesine BugDepartment of Medicine, Hematology/Oncology, Goethe University, Frankfurt, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Little is known about the cellular immune response to SARS-CoV-2 vaccination in patients after HSCT and B-NHL with iatrogenic B-cell aplasia. In nonseroconverted HSCT patients, induction of specific T-cell responses was assessed. The majority of allogeneic HSCT patients not showing humoral responses to vaccination also fail to mount antigen-specific T-cell responses.

Indexed as

COVID-19Hematopoietic Stem Cell TransplantationAntibodies, ViralCOVID-19 VaccinesHumansImmunity, CellularImmunity, HumoralSARS-CoV-2T-LymphocytesVaccinationAntibodies, ViralCOVID-19 VaccinesHSCTSARS-CoV-2SARS-CoV-2-specific T cellsvaccination

Identifiers

PMID35389515
PMCPMC9087431

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.