ArticlePlant physiology2022
SPATULA and ALCATRAZ confer female sterility and fruit cavity via mediating pistil development in cucumber.
Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 28 citations in OpenAlex.
- Integrating BSA-Seq, QTL Mapping, and RNA-Seq to Identify Candidate Genes for Hollow Heart in Cucumber Fruits.Plants (Basel, Switzerland) · 2026Article
- RNA sequencing and histology analysis provide insights into the formation of hollow fruits in cucumber.BMC genomics · 2025Article
- Cytological and Ploidy Analyses Revealing Fertility Defects of CultivarPlants (Basel, Switzerland) · 2025Article
- Fine mapping of the dominant female sterility gene and novel model of hybrid seed production in cabbage (Brassica oleracea L. var. capitata).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- CRISPR mediated gene editing for economically important traits in horticultural crops: progress and prospects.Transgenic research · 2025Review
- Developmental innovation of inferior ovaries and flower sex orchestrated by KNOX1 in cucurbits.Nature plants · 2025Article
- Article
- Evolution of the basic helix-loop-helix transcription factor SPATULA and its role in gynoecium development.Annals of botany · 2024Article
- Comparative transcriptome analysis revealed that auxin and cell wall biosynthesis play important roles in the formation of hollow hearts in cucumber.BMC genomics · 2024Article
- Applications of CRISPR/Cas genome editing in economically important fruit crops: recent advances and future directions.Molecular horticulture · 2023Review
- Pollen tube emergence is mediated by ovary-expressed ALCATRAZ in cucumber.Nature communications · 2023Article
- Genic male and female sterility in vegetable crops.Horticulture research · 2023Article
- Morphological and Genetic Diversity of Cucumber (Plants (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fruits and seeds play essential roles in plant sexual reproduction and the human diet. Successful fertilization involves delivery of sperm in the pollen tube to the egg cell within the ovary along the transmitting tract (TT). Fruit cavity is an undesirable trait directly affecting cucumber (Cucumis sativus) commercial value. However, the regulatory genes underlying fruit cavity formation and female fertility determination remain unknown in crops. Here, we characterized a basic Helix-Loop-Helix (bHLH) gene C. sativus SPATULA (CsSPT) and its redundant and divergent function with ALCATRAZ (CsALC) in cucumber. CsSPT transcripts were enriched in reproductive organs. Mutation of CsSPT resulted in 60% reduction in female fertility, with seed produced only in the upper portion of fruits. Csspt Csalc mutants displayed complete loss of female fertility and fruit cavity due to carpel separation. Further examination showed that stigmas in the double mutant turned outward with defective papillae identity, and extracellular matrix contents in the abnormal TT were dramatically reduced, which resulted in no path for pollen tube extension and no ovules fertilized. Biochemical and transcriptome analysis showed that CsSPT and CsALC act in homodimers and heterodimers to confer fruit cavity and female sterility by mediating genes involved in TT development, auxin-mediated signaling, and cell wall organization in cucumber.
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