ArticleeLife2022
Task-related hemodynamic responses in human early visual cortex are modulated by task difficulty and behavioral performance.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Visual Word Form Area demonstrates individual and task-agnostic consistency but inter-individual variability.Developmental cognitive neuroscience · 2026Article
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- Spatial attention selectively alters visual cortical representation during target anticipation.Nature communications · 2025Article
- Early Visual Cortex Supports One-Shot Episodic Memory via Spatially Tuned Reactivation.bioRxiv : the preprint server for biology · 2025Article
- Heterogeneous Effects of Cognitive Arousal on the Contrast Response in Human Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neural mechanisms of resource allocation in working memory.Science advances · 2025Article
- Behavioural stochastic resonance across the lifespan.Cognitive, affective & behavioral neuroscience · 2024Article
- Central and peripheral haemodynamics at exercise onset: the role of central command.European journal of applied physiology · 2024Article
- Centering cognitive neuroscience on task demands and generalization.Nature neuroscience · 2024Review
- Representations in human primary visual cortex drift over time.Nature communications · 2023Article
- Repairing Artifacts in Neural Activity Recordings Using Low-Rank Matrix Estimation.Sensors (Basel, Switzerland) · 2023Article
- Article
- Morphological Features of Human Dendritic Spines.Advances in neurobiology · 2023Review
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Early visual cortex exhibits widespread hemodynamic responses in the absence of visual stimulation, which are entrained to the timing of a task and not predicted by local spiking or local field potential. Such task-related responses (TRRs) covary with reward magnitude and physiological signatures of arousal. It is unknown, however, if TRRs change on a trial-to-trial basis according to behavioral performance and task difficulty. If so, this would suggest that TRRs reflect arousal on a trial-to-trial timescale and covary with critical task and behavioral variables. We measured functional magnetic resonance imaging blood-oxygen-level-dependent (fMRI-BOLD) responses in the early visual cortex of human observers performing an orientation discrimination task consisting of separate easy and hard runs of trials. Stimuli were presented in a small portion of one hemifield, but the fMRI response was measured in the ipsilateral hemisphere, far from the stimulus representation and focus of spatial attention. TRRs scaled in amplitude with task difficulty, behavioral accuracy, reaction time, and lapses across trials. These modulations were not explained by the influence of respiration, cardiac activity, or head movement on the fMRI signal. Similar modulations with task difficulty and behavior were observed in pupil size. These results suggest that TRRs reflect arousal and behavior on the timescale of individual trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.