Evidence map›Paper›PMID 35389253›Full record

ArticleJournal of bacteriology2022

Staphylococcus aureus Overcomes Anaerobe-Derived Short-Chain Fatty Acid Stress via FadX and the CodY Regulon.

Joshua R Fletcher, Alex R Villareal, Mitchell R Penningroth, Ryan C Hunter

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Volatile biomarkers of Gram-positive bacteria of clinical relevance as a tool for infection diagnosis.International microbiology : the official journal of the Spanish Society for Microbiology · 2024
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Targeting the Achilles' Heel of Multidrug-ResistantInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Joshua R FletcherDepartment of Microbiology & Immunology, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.
Alex R VillarealDepartment of Microbiology & Immunology, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.
Mitchell R PenningrothDepartment of Microbiology & Immunology, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.
Ryan C HunterDepartment of Microbiology & Immunology, University of Minnesotagrid.17635.36, Minneapolis, Minnesota, USA.ORCID 0000-0003-3841-1676
University of Minnesota · US

Funding

Minnesota Craniofacial Research Training ProgramT90DE022732 · NIDCR · UNIVERSITY OF MINNESOTA · PI MANSKY, KIM CARPENTER · 2012 to 2023
$4.9M
Bacterial mucin degradation in cystic fibrosis airway disease.R01HL136919 · NHLBI · UNIVERSITY OF MINNESOTA · PI HUNTER, RYAN COULSON · 2017 to 2021
$2.1M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1R01HL136919HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL136919-03S1NHLBI NIH HHS R01 HL136919NIDCR NIH HHS T90 DE022732
6 · The paper itself

Abstract

Chronic rhinosinusitis (CRS) is characterized by immune dysfunction, mucus hypersecretion, and persistent infection of the paranasal sinuses. While Staphylococcus aureus is a primary CRS pathogen, recent sequence-based surveys have found increased relative abundances of anaerobic bacteria, suggesting that S. aureus may experience altered metabolic landscapes in CRS relative to healthy airways. To test this possibility, we characterized the growth kinetics and transcriptome of S. aureus in supernatants of the abundant CRS anaerobe Fusobacterium nucleatum. While growth was initially delayed, S. aureus ultimately grew to similar levels as in the control medium. The transcriptome was significantly affected by F. nucleatum metabolites, with the

Indexed as

SinusitisStaphylococcal InfectionsBacteriaBacteria, AnaerobicButyratesChronic DiseaseFatty Acids, VolatileHumansPropionatesRegulonStaphylococcus aureusButyratesFatty Acids, VolatilePropionatesanaerobesFusobacteriummicrobiomeshort-chain fatty acidssinusitisStaphylococcus aureus

Identifiers

PMID35389253
PMCPMC9112931
OpenAlexW4225939265

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.