Evidence map›Paper›PMID 35389238›Full record

ArticleAntimicrobial agents and chemotherapy2022

Use of the Hollow-Fiber Infection Model to Measure the Effect of Combination Therapy of Septic Shock Exposures of Meropenem and Ciprofloxacin against Intermediate and Resistant Pseudomonas aeruginosa Clinical Isolates.

Natalija Karabasevic, Jason A Roberts, Luke Stronach, Saiyuri Naicker, Steven C Wallis, Fredrik Sjövall, Fekade Sime

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Natalija KarabasevicMedical Programme, Faculty of Medicine, Lund University, Lund, Sweden.ORCID 0000-0003-0565-644X
Jason A RobertsCentre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queenslandgrid.1003.2, Brisbane, Queensland, Australia.ORCID 0000-0001-6218-435X
Luke StronachCentre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queenslandgrid.1003.2, Brisbane, Queensland, Australia.
Saiyuri NaickerCentre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queenslandgrid.1003.2, Brisbane, Queensland, Australia.
Steven C WallisThe University of Queenslandgrid.1003.2 Centre for Clinical Research, Brisbane, Queensland, Australia.
Fredrik SjövallDepartment of Intensive Care and Perioperative Medicine, Skane University Hospital, Malmö, Sweden.
Fekade SimeCentre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queenslandgrid.1003.2, Brisbane, Queensland, Australia.ORCID 0000-0003-4061-2063

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Meropenem-ciprofloxacin combination therapy was compared to the respective monotherapy in a Hollow-Fiber Infection Model against two Pseudomonas aeruginosa isolates. Following initial kill of ∼ 5-logs by each monotherapy, rapid regrowth occurred within 24 h, reaching 10

Indexed as

Pseudomonas InfectionsShock, SepticAnti-Bacterial AgentsCiprofloxacinHumansMeropenemMicrobial Sensitivity TestsPseudomonas aeruginosaAnti-Bacterial AgentsCiprofloxacinMeropenemcombination therapyHollow-Fiber Infection ModelPseudomonas aeruginosa

Identifiers

PMID35389238
PMCPMC9112939

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.