Evidence map›Paper›PMID 35389185›Full record

ArticleJournal of autism and developmental disorders2023

Volumetric Analysis of Amygdala and Hippocampal Subfields for Infants with Autism.

Guannan Li, Meng-Hsiang Chen, Gang Li, Di Wu, Chunfeng Lian, Quansen Sun, R Jarrett Rushmore, Li Wang

Open access · greenAbstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Guannan Li *School of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China.
Meng-Hsiang Chen *Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Gang LiDepartment of Radiology and Biomedical Research Imaging Center, Bioinformatics Building, University of North Carolina at Chapel Hill, 130 Mason Farm Rd, Chapel Hill, NC, 27599, USA.
Di WuDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Chunfeng LianDepartment of Radiology and Biomedical Research Imaging Center, Bioinformatics Building, University of North Carolina at Chapel Hill, 130 Mason Farm Rd, Chapel Hill, NC, 27599, USA.
Quansen SunSchool of Computer Science and Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China.
R Jarrett RushmoreDepartment of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA.
Li WangDepartment of Radiology and Biomedical Research Imaging Center, Bioinformatics Building, University of North Carolina at Chapel Hill, 130 Mason Farm Rd, Chapel Hill, NC, 27599, USA. li_wang@med.unc.edu.ORCID http://orcid.org/0000-0003-2165-0080
University of North Carolina at Chapel Hill · USBoston University · USChang Gung University · TWNanjing University of Science and Technology · CN

Funding

Continued Development of Infant Brain Analysis ToolsR01MH117943 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, GANG, WANG, LI · 2018 to 2022
$2.3M
Volume-based Analysis of 6-month Infant Brain MRI for Autism Biomarker Identification and Early DiagnosisK01MH109773 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WANG, LI · 2017 to 2020
$571k
NIH HHS MH109773NIH HHS MH117943NIMH NIH HHS K01 MH109773NIMH NIH HHS R01 MH117943
6 · The paper itself

Abstract

Previous studies have demonstrated abnormal brain overgrowth in children with autism spectrum disorder (ASD), but the development of specific brain regions, such as the amygdala and hippocampal subfields in infants, is incompletely documented. To address this issue, we performed the first MRI study of amygdala and hippocampal subfields in infants from 6 to 24 months of age using a longitudinal dataset. A novel deep learning approach, Dilated-Dense U-Net, was proposed to address the challenge of low tissue contrast and small structural size of these subfields. We performed a volume-based analysis on the segmentation results. Our results show that infants who were later diagnosed with ASD had larger left and right volumes of amygdala and hippocampal subfields than typically developing controls.

Indexed as

Autism Spectrum DisorderAutistic DisorderAmygdalaBrainChildHippocampusHumansInfantMagnetic Resonance ImagingAmygdalaAutism spectrum disorder (ASD)Deep learningHippocampus subfieldsInfant structural MRI

Identifiers

PMID35389185
PMCPMC9537344
OpenAlexW4226192537

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.