ArticleThe American journal of pathology1986
Expression of glial fibrillary acidic protein in the CNS and PNS of murine globoid cell leukodystrophy, the twitcher.
Article in The American journal of pathology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 39 citations in OpenAlex.
- Neuroimmunology in globoid cell leukodystrophy: A comprehensive review including treatments, models, and neuroimmune mechanisms underlying neuropathology.Journal of neuroimmunology · 2025Review
- Article
- A neglected neurodegenerative disease: Adult-onset globoid cell leukodystrophy.Frontiers in neuroscience · 2022Review
- Quantitative Microproteomics Based Characterization of the Central and Peripheral Nervous System of a Mouse Model of Krabbe Disease.Molecular & cellular proteomics : MCP · 2019Article
- Long-Term Improvement of Neurological Signs and Metabolic Dysfunction in a Mouse Model of Krabbe's Disease after Global Gene Therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- Biochemical, cell biological, pathological, and therapeutic aspects of Krabbe's disease.Journal of neuroscience research · 2016Review
- Missense mutation in mouse GALC mimics human gene defect and offers new insights into Krabbe disease.Human molecular genetics · 2013Article
- Iron deposition is independent of cellular inflammation in a cerebral model of multiple sclerosis.BMC neuroscience · 2011Article
- Seven kinds of intermediate filament networks in the cytoplasm of polarized cells: structure and function.Acta histochemica et cytochemica · 2010Article
- Clinical and immunopathologic alterations in rhesus macaques affected with globoid cell leukodystrophy.The American journal of pathology · 2008Article
- Spacio-temporal progression of demyelination in twitcher mouse: with clinico-pathological correlation.Acta neuropathologica · 1994Article
- Quantitative aspects of reactive gliosis: a review.Neurochemical research · 1992Review
- The twitcher mouse. An alteration of the unmyelinated fibers in the PNS.The American journal of pathology · 1988Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The expression of glial fibrillary acidic protein (GFAP) was found to be markedly enhanced immunohistochemically and biochemically both in the central (CNS) and peripheral (PNS) nervous systems of the twitcher mutant, an authentic murine model of human globoid cell leukodystrophy. The astrocytes in the CNS, the unmyelinated Schwann cells in the sciatic nerve, and the satellite cells in the trigeminal ganglion stained heavily with anti-GFAP antiserum. These changes in GFAP expression occurred shortly before the initiation of demyelination and coincided chronologically and topographically with infiltration of macrophages, suggesting that the same or closely related factors trigger the infiltration of macrophages and activate expression of GFAP. Cytoskeletal protein preparations showed increases in GFAP as well as in vimentin in the brainstem, spinal cord, and sciatic nerve. These results demonstrate that at least two types of peripheral glia (the unmyelinated Schwann cell and the satellite cell), in addition to the astrocyte, respond to some pathologic stimuli with an increased expression of GFAP. However, two other GFAP-positive structures, the Bergmann and radial glia, showed no significant changes in their immunostaining.
Indexed as
Identifiers
3538889PMC1888232W34507636What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.