ArticleThe New England journal of medicine2022
Implanted System for Orthostatic Hypotension in Multiple-System Atrophy.
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Article in The New England journal of medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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23citing papers in PubMed, 1 pooled it
7.8field-weighted citation impact, top 2% of its field
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- A Pragmatic Review on Spinal Cord Stimulation Therapy for Parkinson's Disease Gait Related Disorders: Gaps and Controversies.Movement disorders clinical practice · 2024Pooled it
- First-in-human study of epidural spinal cord stimulation in individuals with spinal muscular atrophy.Nature medicine · 2025Trial
- Non-invasive spinal cord electrical stimulation for arm and hand function in chronic tetraplegia: a safety and efficacy trial.Nature medicine · 2024Trial
- Predict neuromuscular performance in human epidural electrical stimulation: phase 1 trial interim results.Communications medicine · 2026Article
- Factors associated with orthostatic hypotension presence and severity in multiple system atrophy: a cross-sectional study.Frontiers in neurology · 2026Article
- Approach to Cardiovascular Autonomic Dysfunction in Patients with Synucleinopathies.Movement disorders clinical practice · 2025Review
- Progress and challenges in sporadic late-onset cerebellar ataxias.Nature reviews. Neurology · 2025Review
- From infection to intervention: post-acute sequelae of SARS-CoV-2 infection and cardiovascular risk.Inflammopharmacology · 2025Review
- An implantable system to restore hemodynamic stability after spinal cord injury.Nature medicine · 2025Article
- Neurocardiology: translational advancements and potential.The Journal of physiology · 2025Review
- Review
- Sustained therapeutic effect of spinal cord stimulation on improving severe neurogenic orthostatic hypotension in a patient with pure autonomic failure converting to multiple system atrophy.Journal of neurology · 2025Article
- Article
- Update on the Treatment of Autonomic Disorders.Current treatment options in neurology · 2025Article
- Non-pharmacological and drug treatment of autonomic dysfunction in multiple system atrophy: current status and future directions.Journal of neurology · 2023Review
- Recent updates in autonomic research: a focus on new technologies with high-resolution procedures to study sympathetic nerve activity, plasma proteomic profiling in POTS, and non-invasive neuromodulation with focused ultrasound.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Article
- Transcutaneous Spinal Cord Stimulation Attenuates Blood Pressure Drops in Orthostasis.Life (Basel, Switzerland) · 2022Article
- Natural and targeted circuit reorganization after spinal cord injury.Nature neuroscience · 2022Review
- Long-COVID Syndrome and the Cardiovascular System: A Review of Neurocardiologic Effects on Multiple Systems.Current cardiology reports · 2022Review
- Surgical Management of Synucleinopathies.Biomedicines · 2022Article
Corrections and comments
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Authors and funding
17 authors at 1 institution in 2 countries.
Jordan W SquairFrom the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.
Maxime BerneyFrom the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.
Mayte Castro JimenezFrom the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.ORCID 0000-0003-4165-4804
Nicolas HankovFrom the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.
Robin DemesmaekerFrom the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.
Suje AmirFrom the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.
Aurelie PaleyFrom the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.
Sergio Hernandez-CharpakFrom the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.ORCID 0000-0003-0477-8138
Gregory DumontFrom the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.
Leonie AsbothFrom the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.
Gilles AllenbachFrom the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.
Fabio BecceFrom the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.ORCID 0000-0001-8444-8504
Patrick SchoettkerFrom the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.
Gregoire WuerznerFrom the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.
Julien F BallyFrom the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.
Grégoire CourtineFrom the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.
Jocelyne BlochFrom the Center for Neuroprosthetics and the Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL) (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Department of Clinical Neuroscience (J.W.S., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), the Service of Neurosurgery (J.W.S., G.C., J.B.), the Service of Nephrology and Hypertension (M.B., G.W.), the Service of Neurology (M.C.J., J.F.B.), the Department of Diagnostic and Interventional Radiology (F.B.), and the Service of Anesthesiology (P.S.), Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL-CHUV-UNIL (J.W.S., M.B., N.H., R.D., S.A., A.P., S.H.-C., G.D., L.A., G.C., J.B.), and the Department of Nuclear Medicine and Molecular Imaging, CHUV (G.A.) - all in Lausanne, Switzerland.
Anna Needs Neuroblastoma Answers · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orthostatic hypotension is a cardinal feature of multiple-system atrophy. The upright posture provokes syncopal episodes that prevent patients from standing and walking for more than brief periods. We implanted a system to restore regulation of blood pressure and enable a patient with multiple-system atrophy to stand and walk after having lost these abilities because of orthostatic hypotension. This system involved epidural electrical stimulation delivered over the thoracic spinal cord with accelerometers that detected changes in body position. (Funded by the Defitech Foundation.).
Indexed as
Electric Stimulation TherapyHypotension, OrthostaticMultiple System AtrophyAccelerometryAtrophyBlood PressureElectrodes, ImplantedEpidural SpaceHumansPostureThoracic Vertebrae
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