SynthesisEarly intervention in psychiatry2023
Psychological and contextual risk factors for first-onset depression among adolescents and young people around the globe: A systematic review and meta-analysis.
Synthesis in Early intervention in psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Identifying transdiagnostically relevant risk and protective factors for internalizing psychopathology: An umbrella review of longitudinal meta-analyses.Journal of psychiatric research · 2023Pooled it
- Psychological and contextual risk factors for first-onset depression among adolescents and young people around the globe: A systematic review and meta-analysis.Early intervention in psychiatry · 2023Pooled it
- Associations between inflammation markers (CRP and IL-6) and depression among adolescents and young adults in Soweto and Durban, South Africa.Brain, behavior, & immunity - health · 2026Article
- Development of the FIDES Athlete Development Program 'girls are not small boys': a digital educational intervention.BMJ open sport & exercise medicine · 2026Article
- Co-designing and piloting adolescent-adapted social rhythm therapy for young people with unipolar and bipolar depression: a mixed-methods feasibility case series.Frontiers in child and adolescent psychiatry · 2026Article
- Individual and area-level factors associated with depression in indonesia: a multilevel analysis using the 2018 national basic health research.BMC public health · 2025Article
- Longitudinal Prediction of Adolescent Depression from Environmental and Polygenic Risk Scores.medRxiv : the preprint server for health sciences · 2025Article
- Predicting the onset of mental health problems in adolescents.Psychological medicine · 2025Article
- Mental Distress Among Youths in Low-Income Urban Areas in South America.JAMA network open · 2025Article
- Depression symptoms are associated with demographic characteristics, nutritional status, and social support among young adults in Chile: a latent class analysis.BMC public health · 2024Article
- Differences in bacterial taxa between treatment-naive patients with major depressive disorder and non-affected controls may be related to a proinflammatory profile.BMC psychiatry · 2024Article
- Family Functioning, Maternal Depression, and Adolescent Cognitive Flexibility and Its Associations with Adolescent Depression: A Cross-Sectional Study.Children (Basel, Switzerland) · 2024Article
- Neurocognitive risk phenotyping to predict mood symptoms in adolescence.Journal of psychopathology and clinical science · 2024Article
- Strengthening self-regulation and reducing poverty to prevent adolescent depression and anxiety: Rationale, approach and methods of the ALIVE interdisciplinary research collaboration in Colombia, Nepal and South Africa.Epidemiology and psychiatric sciences · 2023Article
- Fortifying the Foundations: A Comprehensive Approach to Enhancing Mental Health Support in Educational Policies Amidst Crises.Healthcare (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
aimIdentifying predictors for future onset of depression is crucial to effectively developing preventive interventions. We conducted a systematic review and meta-analysis to identify risk factors for first-onset depression among adolescents and young people.
methodsWe searched MEDLINE (Ovid), PsycINFO, Cochrane Database, Web of Science, Lilacs, African Journals Online and Global Health (July 2009 to December 2020) for longitudinal studies assessing risk factors for first-onset depression among adolescents and young people aged 10-25 years. Meta-analyses generated summary odds ratio (OR) estimates. REGISTRATION: PROSPERO CRD42018103973.
resultsNineteen studies representing 21 unique populations were included in the meta-analysis. Among studies reporting race/ethnicity, 79% of participants were of White/European descent. Seventeen studies were from high-income countries, with only two from an upper-middle-income country (China). Odds for first-onset depression were significantly greater for girls compared to boys (n = 13; OR = 1.78 [1.78, 2.28], p < 0.001) and for youth with other mental health problems at baseline (n = 4; OR = 3.20 [1.95, 5.23], p < 0.001). There were non-significant associations for negative family environment (n = 8; OR = 1.60 [0.82, 3.10], p = 0.16) and parental depression (n = 3; OR = 2.30 [0.73, 7.24], p = 0.16).
conclusionsMost longitudinal studies do not report risk factors specifically for first-onset depression. Moreover, predictive data are limited to predominantly White populations in high-income countries. Future research must be more ethnically and geographically representative. Recommendations are provided for consistent and comprehensive reporting of study designs and analyses of risk factors for first-onset depression.
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