ArticleMolecular biology and evolution2022
Transposon Insertion Drove the Loss of Natural Seed Shattering during Foxtail Millet Domestication.
Article in Molecular biology and evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 23 citations in OpenAlex.
- First Observation of Wild Double-FloweredEcology and evolution · 2026Article
- Seed shattering habit in millets and the secrets of the abscission layer - a comprehensive review.Protoplasma · 2026Review
- Genomic and evolutionary analysis reveals dynamic variations of MKK3 gene, a key regulator for seed dormancy in barley.The plant genome · 2026Article
- Stones in genomic storms: transposable element-driven variation in Prunus fruit trees.Mobile DNA · 2026Review
- Histological characteristics, hydrolytic enzyme activity, and changes in plant hormones during the seed-shedding process in two Bromus catharticus Vahl.BMC plant biology · 2026Article
- Seed shattering in a North American Oryzeae grain: Developmental and genomic signatures of early domestication.The plant genome · 2026Article
- Toward improving multiomic research in understudied cereals.Nature genetics · 2025Review
- Transposable elements drive evolution and perturb gene expression in Brassica rapa and B. oleracea.The Plant journal : for cell and molecular biology · 2025Article
- Pangenome analysis reveals yield- and fiber-related diversity and interspecific gene flow in Gossypium barbadense L.Nature communications · 2025Article
- Are cereal grasses a single genetic system?Nature plants · 2024Article
- Crop Evolution of Foxtail Millet.Plants (Basel, Switzerland) · 2024Review
- A graph-based genome and pan-genome variation of the model plant Setaria.Nature genetics · 2023Article
- Grain shattering by cell death and fracture in Eragrostis tef.Plant physiology · 2023Article
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11 authors at 1 institution in 1 country.
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Abstract
Loss of seed shattering was a key step during cereal domestication, and it greatly facilitated seed harvest of the staple cereal foxtail millet (Setaria italica) because the cereal has very small seeds. However, the genetic basis for this loss has been largely unknown. Here, we combined comparative and association mapping to identify an 855-bp Harbinger transposable element insertion in the second exon of the foxtail millet gene shattering1 (sh1) that was responsible for the loss of seed shattering. The sh1 gene encodes zinc finger and YABBY domains. The insert prevents transcription of the second exon, causing partial loss of the zinc finger domain and then loss of natural seed shattering. Specifically, sh1 functions as a transcription repressor and represses the transcription of genes associated with lignin synthesis in the abscission zone, including CAD2. The diversity of sh1 is highly reduced in foxtail millet, consistent with either a severe domestication bottleneck or a selective sweep. Phylogenetic analysis of sh1 further revealed a single origin of foxtail millet in China. Our results support the theories that transposons were the most active factors in genome evolution driving loss of natural seed shattering during foxtail millet domestication and that sh1 underwent parallel selection during domestication across different cereal species.
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