Evidence map›Paper›PMID 35388407›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2022

Altered linear coupling between stimulus-evoked blood flow and oxygen metabolism in the aging human brain.

Monroe P Turner, Yuguang Zhao, Dema Abdelkarim, Peiying Liu, Jeffrey S Spence, Joanna L Hutchison, Dinesh K Sivakolundu, Binu P Thomas, Nicholas A Hubbard, Cuimei Xu and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Temporal and Spatial Scales of Human Resting-State Cortical Activity across the Lifespan.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Monroe P TurnerSchool of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080, USA.
Yuguang ZhaoSchool of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080, USA.
Dema AbdelkarimSchool of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080, USA.
Peiying LiuDepartment of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD 21287, USA.
Jeffrey S SpenceSchool of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080, USA.
Joanna L HutchisonSchool of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080, USA.
Dinesh K SivakolunduSchool of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080, USA.
Binu P ThomasAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
Nicholas A HubbardDepartment of Psychology, Center for Brain, Biology, and Behavior, University of Nebraska, Lincoln, NE 68588, USA.
Cuimei XuDepartment of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD 21287, USA.
Kamil TanejaDepartment of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD 21287, USA.
Hanzhang LuDepartment of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD 21287, USA.
Bart RypmaSchool of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080, USA.
The University of Texas at Dallas · USJohns Hopkins University · USAdvanced Imaging Research (United States) · USUniversity of Nebraska–Lincoln · US

Funding

Testing the Efficacy of Ibudilast to Attenuate Meth-seeking and Associated Synaptic Inflammation at the Synapse (TEAMS)P20GM130461 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI KIMBERLY A TYLER · 2019 to 2026
$20.6M
An integrated vascular MR imaging suite in brain diseasesR01NS106702 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2018 to 2022
$2.7M
MR fingerprinting (MRF) perfusion imaging in cerebral vascular diseaseR01NS106711 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2018 to 2022
$2.2M
BOLD and its discontents: age-differences in the neurophysiology of fMRI signalR01AG047972 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI LU, HANZHANG, RYPMA, BART · 2015 to 2019
$1.7M
Physiological, neural and cognitive bases of age-related working memory changeR01AG029523 · NIA · UNIVERSITY OF TEXAS DALLAS · PI RYPMA, BART · 2007 to 2010
$1.2M
Adolescent Brain Bases of Intergenerational Risk for DepressionF32MH114525 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HUBBARD, NICHOLAS · 2017 to 2019
$123k
NIA NIH HHS R01 AG029523NIA NIH HHS R01 AG047972NIGMS NIH HHS P20 GM130461NIMH NIH HHS F32 MH114525NINDS NIH HHS R01 NS106702NINDS NIH HHS R01 NS106711
6 · The paper itself

Abstract

Neural-vascular coupling (NVC) is the process by which oxygen and nutrients are delivered to metabolically active neurons by blood vessels. Murine models of NVC disruption have revealed its critical role in healthy neural function. We hypothesized that, in humans, aging exerts detrimental effects upon the integrity of the neural-glial-vascular system that underlies NVC. To test this hypothesis, calibrated functional magnetic resonance imaging (cfMRI) was used to characterize age-related changes in cerebral blood flow (CBF) and oxygen metabolism during visual cortex stimulation. Thirty-three younger and 27 older participants underwent cfMRI scanning during both an attention-controlled visual stimulation task and a hypercapnia paradigm used to calibrate the blood-oxygen-level-dependent signal. Measurement of stimulus-evoked blood flow and oxygen metabolism permitted calculation of the NVC ratio to assess the integrity of neural-vascular communication. Consistent with our hypothesis, we observed monotonic NVC ratio increases with increasing visual stimulation frequency in younger adults but not in older adults. Age-related changes in stimulus-evoked cerebrovascular and neurometabolic signal could not fully explain this disruption; increases in stimulus-evoked neurometabolic activity elicited corresponding increases in stimulus-evoked CBF in younger but not in older adults. These results implicate age-related, demand-dependent failures of the neural-glial-vascular structures that comprise the NVC system.

Indexed as

Neurovascular CouplingAgedAgingAnimalsBrainCerebrovascular CirculationHumansMagnetic Resonance ImagingMiceOxygenOxygenagingcalibrated fMRIcerebral blood flowcerebral oxygen metabolismneurovascular coupling

Identifiers

PMID35388407
PMCPMC9758587
OpenAlexW4210754564

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.