Evidence map›Paper›PMID 35388406›Full record

ArticleAmerican journal of epidemiology2023

Illustration of 2 Fusion Designs and Estimators.

Stephen R Cole, Jessie K Edwards, Alexander Breskin, Samuel Rosin, Paul N Zivich, Bonnie E Shook-Sa, Michael G Hudgens

Abstract read
In one paragraph

Article in American journal of epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Combining Observational Studies to Reduce Multiple Biases.Epidemiology (Cambridge, Mass.) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. A minimal nontrivial example of higher-order evidence.American journal of epidemiology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Higher-order evidence.European journal of epidemiology · 2024
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stephen R Cole
Jessie K Edwards
Alexander Breskin
Samuel Rosin
Paul N Zivich
Bonnie E Shook-Sa
Michael G Hudgens

Funding

Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
UNC MACS/WIHS Combined Cohort Study Clinical Research SiteU01HL146194 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Michael Bradley Drummond, Michelle Floris-Moore · 2019 to 2026
$23.2M
University of North Carolina Womens Interagency HIV Study UNC WIHSU01AI103390 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ADIMORA, ADAORA A · 2013 to 2018
$11.0M
Training in Sexually Transmitted Infections and HIVT32AI007001 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SENA-SOBERANO, ARLENE C. · 1985 to 2025
$10.9M
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
Improved analysis of experiments and observational studies in HIVR01AI157758 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephen R Cole, Jessie Edwards · 2020 to 2026
$5.0M
From Biological to Social Processes: Interdisciplinary Training in Life Course ResearchT32HD091058 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT A HUMMER, Amanda L Thompson · 2017 to 2026
$4.3M
Comparative effectiveness of tailored HIV treatment plans and mortalityK01AI125087 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI EDWARDS, JESSIE · 2017 to 2021
$586k
NHLBI NIH HHS U01 HL146194NIAID NIH HHS K01 AI125087NIAID NIH HHS P30 AI050410NIAID NIH HHS R01 AI157758NIAID NIH HHS T32 AI007001NICHD NIH HHS P2C HD050924NICHD NIH HHS T32 HD091058
6 · The paper itself

Abstract

"Fusion" study designs combine data from different sources to answer questions that could not be answered (as well) by subsets of the data. Studies that augment main study data with validation data, as in measurement-error correction studies or generalizability studies, are examples of fusion designs. Fusion estimators, here solutions to stacked estimating functions, produce consistent answers to identified research questions using data from fusion designs. In this paper, we describe a pair of examples of fusion designs and estimators, one where we generalize a proportion to a target population and one where we correct measurement error in a proportion. For each case, we present an example motivated by human immunodeficiency virus research and summarize results from simulation studies. Simulations demonstrate that the fusion estimators provide approximately unbiased results with appropriate 95% confidence interval coverage. Fusion estimators can be used to appropriately combine data in answering important questions that benefit from multiple sources of information.

Indexed as

Research DesignComputer SimulationHumansaccuracybiasgeneralizabilitymeasurement errorrandom errorstudy design

Identifiers

PMID35388406
PMCPMC10372880

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.