Evidence map›Paper›PMID 35388375›Full record

ArticleNeurographics (2011)2018

Complications of Radiotherapy and Radiosurgery in the Brain and Spine.

G Barisano, S Bergamaschi, J Acharya, A Rajamohan, W Gibbs, P Kim, G Zada, E Chang, M Law

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurographics (2011), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Failure of gamma knife radiosurgery for sporadic vestibular schwannomas: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Pooled it
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  6. Age-related risk factors and treatment outcomes in geriatric patients with spinal low-grade glioma: A nationwide analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
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  20. Foreign Contaminants Target Brain Health.CNS & neurological disorders drug targets · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

G BarisanoDepartments of Radiology (G.B., S.B., J.A., A.R., W.G., P.K., M.L.), Neurosurgery (G.Z.), Radiation Oncology (E.C.), and Stevens Institute of Neuroimaging and Informatics (M.L.), University of Southern California, Los Angeles, California.
S BergamaschiDepartments of Radiology (G.B., S.B., J.A., A.R., W.G., P.K., M.L.), Neurosurgery (G.Z.), Radiation Oncology (E.C.), and Stevens Institute of Neuroimaging and Informatics (M.L.), University of Southern California, Los Angeles, California.
J AcharyaDepartments of Radiology (G.B., S.B., J.A., A.R., W.G., P.K., M.L.), Neurosurgery (G.Z.), Radiation Oncology (E.C.), and Stevens Institute of Neuroimaging and Informatics (M.L.), University of Southern California, Los Angeles, California.
A RajamohanDepartments of Radiology (G.B., S.B., J.A., A.R., W.G., P.K., M.L.), Neurosurgery (G.Z.), Radiation Oncology (E.C.), and Stevens Institute of Neuroimaging and Informatics (M.L.), University of Southern California, Los Angeles, California.
W GibbsDepartments of Radiology (G.B., S.B., J.A., A.R., W.G., P.K., M.L.), Neurosurgery (G.Z.), Radiation Oncology (E.C.), and Stevens Institute of Neuroimaging and Informatics (M.L.), University of Southern California, Los Angeles, California.
P KimDepartments of Radiology (G.B., S.B., J.A., A.R., W.G., P.K., M.L.), Neurosurgery (G.Z.), Radiation Oncology (E.C.), and Stevens Institute of Neuroimaging and Informatics (M.L.), University of Southern California, Los Angeles, California.
G ZadaDepartments of Radiology (G.B., S.B., J.A., A.R., W.G., P.K., M.L.), Neurosurgery (G.Z.), Radiation Oncology (E.C.), and Stevens Institute of Neuroimaging and Informatics (M.L.), University of Southern California, Los Angeles, California.
E ChangDepartments of Radiology (G.B., S.B., J.A., A.R., W.G., P.K., M.L.), Neurosurgery (G.Z.), Radiation Oncology (E.C.), and Stevens Institute of Neuroimaging and Informatics (M.L.), University of Southern California, Los Angeles, California.
M LawDepartments of Radiology (G.B., S.B., J.A., A.R., W.G., P.K., M.L.), Neurosurgery (G.Z.), Radiation Oncology (E.C.), and Stevens Institute of Neuroimaging and Informatics (M.L.), University of Southern California, Los Angeles, California.
University of Southern California · US

Funding

VASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARANDA, MARIA P. · 1985 to 2019
$41.0M
Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's DiseaseP01AG052350 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation, ARTHUR W TOGA · 2016 to 2026
$28.4M
Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel DiseaseUH3NS100614 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KASHANI, AMIR H, RINGMAN, JOHN M · 2018 to 2020
$4.3M
Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel DiseaseUH2NS100614 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KASHANI, AMIR H, RINGMAN, JOHN M · 2016 to 2017
$2.4M
Area B: Precise DCE-MRI Assessment of Brain TumorsR33CA225400 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NAYAK, KRISHNA S · 2017 to 2017
$1.6M
Faster MRI with Sparse Sampling and Low-Rank ModelingR21EB022951 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HALDAR, JUSTIN PRITAM · 2016 to 2017
$430k
A Novel System for Reducing Radiation Dose of CT PerfusionR41EB024438 · NIBIB · HURA IMAGING, INC · PI WANG, DANNY JJ · 2017 to 2017
$266k
NCI NIH HHS R33 CA225400NIA NIH HHS P01 AG052350NIA NIH HHS P50 AG005142NIBIB NIH HHS R21 EB022951NIBIB NIH HHS R41 EB024438NINDS NIH HHS UH2 NS100614NINDS NIH HHS UH3 NS100614
6 · The paper itself

Abstract

Radiation therapy is an integral part of the standard of care for many patients with brain and spine tumors. Stereotactic radiation surgery is increasingly being used as an adjuvant therapy as well as a sole treatment. However, despite newer and more focused techniques, radiation therapy still causes significant neurotoxicity. In this article, we reviewed the scientific literature, presented cases of patients who had developed different complications related to conventional radiation therapy or radiosurgery (gamma knife), demonstrated the imaging findings, and discussed the relevant clinical information for the correct diagnoses. Radiation therapy can cause injury in different ways: directly damaging the structures included in the radiation portal, indirectly affecting the blood vessels, and increasing the chance of tumor development. We also divided radiation complications according to the time of occurrence: acute (0 to 4 weeks), early delayed (4 weeks to months), and late delayed (months to years). With the increasing application of radiation therapy for the treatment of CNS tumors, it is important for the neuroradiologist to recognize the many possible complications of radiation therapy. Although this may cause significant diagnostic challenges, understanding the pathophysiology, time course of onset, and imaging features may help institute early therapy and prevent possible deleterious outcomes. Learning Objectives: To recognize the main complications of radiation therapy and stereotactic radiosurgery in the brain and spine, and to highlight the imaging findings to improve the diagnostic process and treatment planning.

Identifiers

PMID35388375
PMCPMC8981962
OpenAlexW2805712232

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.