Evidence map›Paper›PMID 35388276›Full record

ArticlePrzeglad menopauzalny = Menopause review2022

Sildenafil citrate as an adjuvant to clomiphene citrate for ovulation induction in polycystic ovary syndrome: crossover randomized controlled trial.

Walid E Mohammed, Mustafa M Abbas, Ibrahim A Abdelazim, Mohammed M Salman

Open access · goldAbstract read
In one paragraph

Article in Przeglad menopauzalny = Menopause review, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Vasodilators for women undergoing fertility treatment.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Relation between vitamin D and adolescents' serum prolactin.Przeglad menopauzalny = Menopause review · 2023
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Walid E MohammedDepartment of Obstetrics and Gynaecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Mustafa M AbbasDepartment of Obstetrics and Gynaecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Ibrahim A AbdelazimDepartment of Obstetrics and Gynaecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Mohammed M SalmanDepartment of Obstetrics and Gynaecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Ain Shams University · EGKuwait Petroleum Corporation (Kuwait) · KW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: To evaluate sildenafil citrate as an adjuvant to clomiphene citrate (CC) for ovulation induction (OI) in women with polycystic ovary syndrome (PCOS). Material and methods: A total of 595 infertile PCOS women were randomly assigned into either clomiphene/sildenafil (C/S) group or CC group. Transvaginal (TVS)-Doppler studies were done for participants when the dominant follicle reach 16 mm, to measure the resistance index, pulsatility index, and maximum velocity of sub-endometrial, uterine, and ovarian vessels. Participants were examined using TVS on the 21 Results: The endometrial thickness was significantly higher among the C/S than the CC group during the first 3 months (9.6 ±1.2 vs. 8.7 ±1.0 mm, respectively, Conclusions: SC as an adjuvant to CC for OI in PCOS women increases the chemical and clinical pregnancy rates. It also improves the endometrial thickness and ovulation rate through improved endometrial and ovarian Doppler indices.

Indexed as

clomiphene citrateinduction of ovulationPCOSsildenafil citrate

Identifiers

PMID35388276
PMCPMC8966415
OpenAlexW4211159685

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.