Evidence map›Paper›PMID 35388227›Full record

ArticleCanadian journal of veterinary research = Revue canadienne de recherche veterinaire2022

The pharmacokinetics and pharmacodynamics of midazolam after intravenous administration to donkeys

Odette O, Bradley T Simon, Lisa S Ebner, Ignacio Lizarraga, Xiaocun Sun, Sherry K Cox

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Donkey Heart Rate and Heart Rate Variability: A Scoping Review.Animals : an open access journal from MDPI · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Odette ODepartment of Clinical Sciences (O) and Department of Biomedical Sciences (Lizarraga), Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and Nevis; Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas 77845, USA (Simon); College of Veterinary Medicine, Lincoln Memorial University, Harrogate, Tennessee 37752, USA (Ebner); Office of Information and Technology, University of Tennessee, Knoxville, Tennessee, USA (Sun); Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA (Cox).
Bradley T SimonDepartment of Clinical Sciences (O) and Department of Biomedical Sciences (Lizarraga), Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and Nevis; Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas 77845, USA (Simon); College of Veterinary Medicine, Lincoln Memorial University, Harrogate, Tennessee 37752, USA (Ebner); Office of Information and Technology, University of Tennessee, Knoxville, Tennessee, USA (Sun); Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA (Cox).
Lisa S EbnerDepartment of Clinical Sciences (O) and Department of Biomedical Sciences (Lizarraga), Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and Nevis; Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas 77845, USA (Simon); College of Veterinary Medicine, Lincoln Memorial University, Harrogate, Tennessee 37752, USA (Ebner); Office of Information and Technology, University of Tennessee, Knoxville, Tennessee, USA (Sun); Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA (Cox).
Ignacio LizarragaDepartment of Clinical Sciences (O) and Department of Biomedical Sciences (Lizarraga), Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and Nevis; Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas 77845, USA (Simon); College of Veterinary Medicine, Lincoln Memorial University, Harrogate, Tennessee 37752, USA (Ebner); Office of Information and Technology, University of Tennessee, Knoxville, Tennessee, USA (Sun); Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA (Cox).
Xiaocun SunDepartment of Clinical Sciences (O) and Department of Biomedical Sciences (Lizarraga), Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and Nevis; Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas 77845, USA (Simon); College of Veterinary Medicine, Lincoln Memorial University, Harrogate, Tennessee 37752, USA (Ebner); Office of Information and Technology, University of Tennessee, Knoxville, Tennessee, USA (Sun); Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA (Cox).
Sherry K CoxDepartment of Clinical Sciences (O) and Department of Biomedical Sciences (Lizarraga), Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and Nevis; Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas 77845, USA (Simon); College of Veterinary Medicine, Lincoln Memorial University, Harrogate, Tennessee 37752, USA (Ebner); Office of Information and Technology, University of Tennessee, Knoxville, Tennessee, USA (Sun); Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA (Cox).
Lincoln Memorial University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pharmacokinetics and pharmacodynamics of midazolam were studied in eight 1-to-3-year-old healthy gelded donkeys. Blood samples were obtained. Heart rate, respiratory rate, rectal temperature, sedation/excitement, ataxia, and response to tactile and auditory stimuli were recorded at baseline until 48 hours after intravenous (IV) midazolam (0.1 mg/kg) administration. Plasma midazolam and 1-hydroxymidazolam were measured using reversed-phase high-performance liquid chromatography. Pharmacokinetic variables were calculated using non-compartmental analysis. Physiologic data were analyzed using a mixed-effects model followed by Dunnett's test and behavioral data were analyzed using a Friedman test then a Dunn's test;

Indexed as

EquidaeMidazolamAdministration, IntravenousAnimalsAtaxiaHalf-LifeMidazolam

Identifiers

PMID35388227
PMCPMC8978292
OpenAlexW4223424569

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.