Evidence map›Paper›PMID 35388222›Full record

ArticleNature2022

A complete temporal transcription factor series in the fly visual system.

Nikolaos Konstantinides, Isabel Holguera, Anthony M Rossi, Aristides Escobar, Liébaut Dudragne, Yen-Chung Chen, Thinh N Tran, Azalia M Martínez Jaimes, Mehmet Neset Özel, Félix Simon and 6 more

Open access · greenAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 136 citations in OpenAlex.

  1. Article
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  4. Regulatory logic of neuronal differentiation in theProceedings of the National Academy of Sciences of the United States of America · 2026
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  7. Harnessing the Power ofCold Spring Harbor perspectives in biology · 2026
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  10. Modern Mining: The Role of Single-cell RNA Sequencing in Advancing Neuroscience Research.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  11. Article
  12. Temporal neuronal differentiation programs safeguard neuronal diversity.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  13. Article
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  15. Ontogeny of the spinal cord dorsal horn.Science (New York, N.Y.) · 2026
    Article
  16. Regulatory logic of neuronal identity specification inbioRxiv : the preprint server for biology · 2025
    Article
  17. Article
  18. Cell cycle-dependent cues regulate temporal patterning of thebioRxiv : the preprint server for biology · 2025
    Article
  19. Article
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 4 countries.

Nikolaos Konstantinides *Department of Biology, New York University, New York, NY, USA. nikos.konstantinides@ijm.fr.ORCID http://orcid.org/0000-0002-9525-2838
Isabel Holguera *Department of Biology, New York University, New York, NY, USA.ORCID http://orcid.org/0000-0003-2796-6596
Anthony M Rossi *Department of Biology, New York University, New York, NY, USA.ORCID http://orcid.org/0000-0001-9345-7939
Aristides EscobarDepartment of Biology, New York University, New York, NY, USA.
Liébaut DudragneDepartment of Biology, New York University, New York, NY, USA.
Yen-Chung ChenDepartment of Biology, New York University, New York, NY, USA.ORCID http://orcid.org/0000-0002-8529-1251
Thinh N TranDepartment of Biology, New York University, New York, NY, USA.ORCID http://orcid.org/0000-0002-3428-2507
Azalia M Martínez JaimesDepartment of Biology, New York University, New York, NY, USA.
Mehmet Neset ÖzelDepartment of Biology, New York University, New York, NY, USA.ORCID http://orcid.org/0000-0002-0185-5866
Félix SimonDepartment of Biology, New York University, New York, NY, USA.
Zhiping ShaoDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, Institute for Genomics and Multiscale Biology, New York, NY, USA.
Nadejda M TsankovaDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
John F FullardDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, Institute for Genomics and Multiscale Biology, New York, NY, USA.ORCID http://orcid.org/0000-0001-9874-2907
Uwe WalldorfDevelopmental Biology, Saarland University, Homburg, Germany.
Panos RoussosDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, Institute for Genomics and Multiscale Biology, New York, NY, USA.ORCID http://orcid.org/0000-0002-4640-6239
Claude DesplanDepartment of Biology, New York University, New York, NY, USA. cd38@nyu.edu.ORCID http://orcid.org/0000-0002-6914-1413
New York University · USIcahn School of Medicine at Mount Sinai · USNew York University Abu Dhabi · AEHarvard University · USJames J. Peters VA Medical Center · USNikon (United States) · USSaarland University · DE

Funding

Signaling from photoreceptors to the optic lobesR01EY013012 · NEI · NEW YORK UNIVERSITY · PI DESPLAN, CLAUDE · 1999 to 2024
$9.4M
Neurogenesis of the optic lobesR01EY017916 · NEI · NEW YORK UNIVERSITY · PI Claude Desplan · 2007 to 2026
$8.0M
TRAINING PROGRAM IN DEVELOPMENTAL GENETICS.T32HD007520 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TREISMAN, JESSICA E · 1999 to 2023
$3.9M
Chromatin Plasticity, Transcriptional Activity and Kinetics in Developing and Adult Human Astrocyte and Oligodendroglial LineagesRF1DA048810 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI TSANKOVA, NADEJDA MINCHEVA · 2019 to 2019
$1.8M
Developmental and evolutionary basis of neuronal diversityK99EY029356 · NEI · NEW YORK UNIVERSITY · PI KONSTANTINIDES, NIKOLAOS · 2018 to 2019
$253k
NEI NIH HHS K99 EY029356NEI NIH HHS R01 EY013012NEI NIH HHS R01 EY017916NICHD NIH HHS T32 HD007520NIDA NIH HHS RF1 DA048810NIH HHS EY019716
6 · The paper itself

Abstract

The brain consists of thousands of neuronal types that are generated by stem cells producing different neuronal types as they age. In Drosophila, this temporal patterning is driven by the successive expression of temporal transcription factors (tTFs)

Indexed as

Drosophila melanogasterDrosophila ProteinsGene Expression Regulation, DevelopmentalOptic Lobe, NonmammalianTranscription FactorsVision, OcularVisual PerceptionAnimalsNeural Stem CellsNeuronsRNA-SeqSingle-Cell AnalysisDrosophila ProteinsTranscription Factors

Identifiers

PMID35388222
PMCPMC9074256
OpenAlexW4224094774

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.