ArticleNature2022
Structural basis of lipopolysaccharide maturation by the O-antigen ligase.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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0cells of the map it votes in
38citing papers in PubMed
9.4field-weighted citation impact, top 2% of its field
What it found
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Who cites it
38 citing papers in PubMed, 55 citations in OpenAlex.
- When folding CARDs wins the game: molecular snapshots of lipopolysaccharide sensing by the non-canonical inflammasome.Biochemical Society transactions · 2026Review
- Structural basis of glucosinolate recognition and transport by plant GTR1.Cell discovery · 2026Article
- Cargo Secreted by the Type IX Secretion System of Porphyromonas gingivalis Are Tethered to O-Lipopolysaccharides via a Pentasaccharide Linker.MicrobiologyOpen · 2026Article
- Conformational ensembles of the magnesium channel CorA reveal structural basis for channel gating.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Antimicrobial Peptide Activity in Lipid Bilayers with Smooth-Type Lipopolysaccharides.Analytical chemistry · 2026Article
- Expression and Purification of Integral Membrane Enzymes for Functional and Structural Studies.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Structural Basis of Lipopolysaccharide O-Antigen Chain Length Modality.Research (Washington, D.C.) · 2026Article
- Article
- CCD2MD: A Suite of Packages for Preparing Co-Folded Outputs for Molecular Dynamics Simulations.Journal of chemical information and modeling · 2025Article
- Structural basis of lipopolysaccharide assembly by the outer membrane translocon holo-complex.Nature communications · 2025Article
- Wzy 3D structural models correlate with inter-repeat unit glycosidic bond configuration in pneumococcal capsule polysaccharides.Microbiology spectrum · 2025Article
- Article
- AcuteMicroorganisms · 2025Article
- Structural Insights into the Protein Mannosyltransferase from Mycobacterium tuberculosis reveal a WW-Domain-Like Protein Motif in Bacteria.Communications biology · 2025Article
- Supramolecular Detoxification Approach of Endotoxin Through Host-Guest Complexation by a Giant Macrocycle.Molecules (Basel, Switzerland) · 2025Article
- O-antigen polysaccharides inMicrobiology and molecular biology reviews : MMBR · 2025Review
- Structural insights into terminal arabinosylation of mycobacterial cell wall arabinan.Nature communications · 2025Article
- Structural insights into polyisoprenyl-binding glycosyltransferases.Structure (London, England : 1993) · 2025Review
- Structural glycobiology - from enzymes to organelles.Biochemical Society transactions · 2025Review
- Structure of WzxE the lipid III flippase for Enterobacterial Common Antigen polysaccharide.Open biology · 2025Article
Corrections and comments
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Authors and funding
23 authors at 7 institutions in 3 countries.
Khuram U AshrafDepartment of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-0799-4947
Rie NygaardDepartment of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.
Owen N Vickery *School of Life Sciences, University of Warwick, Coventry, UK.
Satchal K Erramilli *Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-8694-7681
Carmen M Herrera *Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
Thomas H McConville *Department of Medicine, Division of Infectious Diseases, Columbia University Medical Center, New York, NY, USA.
Vasileios I PetrouDepartment of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers Biomedical Health Sciences, Newark, NJ, USA.ORCID http://orcid.org/0000-0002-3194-9863
Sabrina I GiacomettiDepartment of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.
Meagan Belcher DufrisneDepartment of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.
Kamil NosolDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-2865-9125
Allen P ZinkleDepartment of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.
Chris L B GrahamSchool of Life Sciences, University of Warwick, Coventry, UK.ORCID http://orcid.org/0000-0002-4271-6731
Michael LoukerisNew York Consortium on Membrane Protein Structure, New York Structural Biology Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-1697-2563
Brian KlossNew York Consortium on Membrane Protein Structure, New York Structural Biology Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-0130-8739
Karolina Skorupinska-TudekInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
Ewa SwiezewskaInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
David I RoperDepartment of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-0009-621X
Oliver B ClarkeDepartment of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-1876-196X
Anne-Catrin UhlemannDepartment of Medicine, Division of Infectious Diseases, Columbia University Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-9798-4768
Anthony A KossiakoffDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
M Stephen TrentDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, USA. strent@uga.edu.ORCID http://orcid.org/0000-0001-6134-1800
Phillip J StansfeldSchool of Life Sciences, University of Warwick, Coventry, UK. phillip.stansfeld@warwick.ac.uk.ORCID http://orcid.org/0000-0001-8800-7669
Filippo ManciaDepartment of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY, USA. fm123@cumc.columbia.edu.ORCID http://orcid.org/0000-0003-3293-2200
Columbia University Irving Medical Center · USUniversity of Chicago · USUniversity of Warwick · GBInstitute of Biochemistry and Biophysics, Polish Academy of Sciences · PLNew York Structural Biology Center · USUniversity of Georgia · USRutgers, The State University of New Jersey · US
Funding
Transcriptional Regulation of Urothelial Differentiation During Homeostasis and Repair in Response to Urinary Tract InfectionU54DK104309 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JONATHAN M. BARASCH, ALI G GHARAVI · 2014 to 2026
$17.7MTraining (303-338)P41GM116799 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI HENDRICKSON, WAYNE A. · 2016 to 2020
$7.1MChaperone-Assisted Structure Determination of Membrane ProteinsR01GM117372 · NIGMS · UNIVERSITY OF CHICAGO · PI ANTHONY A KOSSIAKOFF · 2016 to 2026
$4.0MThe Cell Envelope of the Multi-Drug Resistant Pathogen Acinetobacter baumanniiR01AI150098 · NIAID · UNIVERSITY OF GEORGIA · PI Michael Stephen Trent · 2020 to 2026
$3.9MStructural basis of integral membrane enzyme functionR35GM132120 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Filippo Mancia · 2019 to 2026
$3.7MDevelopment of a novel vaccine platform: Surface Antigen/Adjuvant Vaccine Engineering (SAAVE)R01AI129940 · NIAID · UNIVERSITY OF GEORGIA · PI TRENT, MICHAEL STEPHEN · 2017 to 2021
$3.3MColumbia Integrated Training Program in Infectious Diseases ResearchT32AI100852 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAGDALENA ELZBIETA SOBIESZCZYK, Anne-Catrin Uhlemann · 2013 to 2026
$2.2MMolecular mechanisms required for the maintenance of the gram-negative outer membraneR01AI138576 · NIAID · UNIVERSITY OF GEORGIA · PI TRENT, MICHAEL STEPHEN · 2018 to 2022
$2.0MElucidating the genotypic determinants and phenotypic effects of polymyxin resistance in Klebsiella pneumoniae utilizing CRISPR-Cas9K08AI146284 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MCCONVILLE, THOMAS HOWE · 2020 to 2024
$962kSTRUCTURAL BASIS OF AMINORABINOSE BIOSYNTHESIS LINKED TO POLYMYXIN RESISTANCER00GM123228 · NIGMS · RBHS-NEW JERSEY MEDICAL SCHOOL · PI PETROU, VASILEIOS I · 2019 to 2021
$747kStructural basis of aminoarabinose biosynthesis linked to polymyxin resistanceK99GM123228 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PETROU, VASILEIOS I · 2017 to 2018
$180kMedical Research Council MR/N002679/1Medical Research Council MR/S009213/1Medical Research Council S009213/1NIAID NIH HHS K08 AI146284NIAID NIH HHS R01 AI129940NIAID NIH HHS R01 AI138576NIAID NIH HHS R01 AI150098NIAID NIH HHS T32 AI100852NIDDK NIH HHS U54 DK104309NIGMS NIH HHS K99 GM123228NIGMS NIH HHS P41 GM116799NIGMS NIH HHS R00 GM123228NIGMS NIH HHS R01 GM117372NIGMS NIH HHS R35 GM132120NIH HHS AI129940NIH HHS AI150098NIH HHS GM116799NIH HHS GM117372NIH HHS GM132120Wellcome TrustWellcome Trust 208361/Z/17/Z
Abstract
The outer membrane of Gram-negative bacteria has an external leaflet that is largely composed of lipopolysaccharide, which provides a selective permeation barrier, particularly against antimicrobials
Indexed as
LigasesLipopolysaccharidesO AntigensBacterial ProteinsCarbon-Oxygen LigasesCryoelectron MicroscopyGlycosyltransferasesGram-Negative BacteriaBacterial ProteinsCarbon-Oxygen LigasesGlycosyltransferasesLigasesLipopolysaccharidesO Antigens
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