Evidence map›Paper›PMID 35388214›Full record

ArticleNature2022

Capturing a rhodopsin receptor signalling cascade across a native membrane.

Siyun Chen, Tamar Getter, David Salom, Di Wu, Daniel Quetschlich, Dror S Chorev, Krzysztof Palczewski, Carol V Robinson

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 78 citations in OpenAlex.

  1. Review
  2. Ciliary Membrane Lipid Homeostasis in Health and Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Article
  4. Two-step mechanism of Bruton's tyrosine kinase membrane recruitment and activation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Role and Impact of theInternational journal of molecular sciences · 2026
    Article
  9. The Nanodisc System for Investigating Protein-Lipid Interactions.Methods in molecular biology (Clifton, N.J.) · 2026
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Thermal Remodeling of Human HDL Particles Reveals Diverse Subspecies.Journal of the American Society for Mass Spectrometry · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Siyun ChenChemistry Research Laboratory, University of Oxford, Oxford, UK.
Tamar GetterGavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, Irvine, CA, USA.
David SalomGavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, Irvine, CA, USA.
Di WuChemistry Research Laboratory, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-9748-4408
Daniel QuetschlichChemistry Research Laboratory, University of Oxford, Oxford, UK.
Dror S ChorevChemistry Research Laboratory, University of Oxford, Oxford, UK. drorchorev@gmail.com.
Krzysztof PalczewskiGavin Herbert Eye Institute, Department of Ophthalmology, University of California, Irvine, Irvine, CA, USA. kpalczew@uci.edu.ORCID http://orcid.org/0000-0002-0788-545X
Carol V RobinsonChemistry Research Laboratory, University of Oxford, Oxford, UK. carol.robinson@chem.ox.ac.uk.ORCID http://orcid.org/0000-0001-7829-5505
University of Oxford · GBUniversity of California, Irvine · US

Funding

Opsin signaling in mammalian rod photoreceptorsR01EY030912 · NEI · WASHINGTON UNIVERSITY · PI KEFALOV, VLADIMIR JIVKOV, PALCZEWSKI, KRZYSZTOF · 2020 to 2023
$1.6M
NEI NIH HHS R01 EY030912Wellcome TrustWellcome Trust 221795/Z/20/Z
6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) are cell-surface receptors that respond to various stimuli to induce signalling pathways across cell membranes. Recent progress has yielded atomic structures of key intermediates

Indexed as

OpsinsRhodopsinTransducinIsomerismLipid MetabolismOptic DiskPhosphatidylcholinesProtein ConformationReceptors, G-Protein-CoupledOpsinsPhosphatidylcholinesReceptors, G-Protein-CoupledRhodopsinTransducin

Identifiers

PMID35388214
PMCPMC9007743
OpenAlexW4224006395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.