Evidence map›Paper›PMID 35388098›Full record

ArticleScientific reports2022

Site specific incidence rate of genomic subtypes of enteropathogenic Escherichia coli and association with enteric inflammation and child growth.

Rina Das, Parag Palit, Md Ahshanul Haque, Mustafa Mahfuz, A S G Faruque, Tahmeed Ahmed

Abstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rina DasEmeritus Scientist, Nutrition and Clinical Services Division, icddr,b, 68 Shaheed Tajuddin Ahmed Sharani, Dhaka, 1212, Bangladesh.
Parag PalitEmeritus Scientist, Nutrition and Clinical Services Division, icddr,b, 68 Shaheed Tajuddin Ahmed Sharani, Dhaka, 1212, Bangladesh.
Md Ahshanul HaqueEmeritus Scientist, Nutrition and Clinical Services Division, icddr,b, 68 Shaheed Tajuddin Ahmed Sharani, Dhaka, 1212, Bangladesh.
Mustafa MahfuzEmeritus Scientist, Nutrition and Clinical Services Division, icddr,b, 68 Shaheed Tajuddin Ahmed Sharani, Dhaka, 1212, Bangladesh.
A S G FaruqueEmeritus Scientist, Nutrition and Clinical Services Division, icddr,b, 68 Shaheed Tajuddin Ahmed Sharani, Dhaka, 1212, Bangladesh. gfaruque@icddrb.org.
Tahmeed AhmedEmeritus Scientist, Nutrition and Clinical Services Division, icddr,b, 68 Shaheed Tajuddin Ahmed Sharani, Dhaka, 1212, Bangladesh.

Funding

Bill & Melinda Gates Foundation OPP47075
6 · The paper itself

Abstract

There is a lack of information highlighting the possible association between the genomic subtypes of enteropathogenic Escherichia coli (EPEC) on environmental enteric dysfunction (EED) and on linear growth during childhood. Genomic subtypes of EPEC from stool samples collected from 1705 children enrolled in the MAL-ED birth cohort were detected by TaqMan Array Cards. We measured site-specific incidence rate by using Poisson regression models, identified the risk factors and estimated the association of genomic subtypes of EPEC with the composite EED score and linear growth at 24 months of age. In general, the highest incidence rate (39%) was found among children having aEPEC infection, which was the greatest in Tanzania (54%). Exclusive breastfeeding and having an improved sanitation facility were found to be protective factors against EPEC infection. In the multivariate models, in overall effect after adjusting for the potential covariates aEPEC showed strong positive associations with the EED scores and tEPEC showed a positive association with poor linear growth at 24 months of age. Our analyses may lay the cornerstone for a prospective epidemiologic investigation for a potential vaccine development aimed at reducing the burden of EPEC infections and combat childhood malnutrition.

Indexed as

Enteropathogenic Escherichia coliEscherichia coli InfectionsEscherichia coli ProteinsChildDiarrheaFemaleHumansIncidenceInflammationProspective StudiesEscherichia coli Proteins

Identifiers

PMID35388098
PMCPMC8986875

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.