ArticleNature communications2022
Zoonotic origin of the human malaria parasite Plasmodium malariae from African apes.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- The threat of increased transmission of non-Parasitology · 2023Pooled it
- Identification of two genomic cryptotypes of Plasmodium malariae in Africa.PLoS neglected tropical diseases · 2026Article
- Population genomics of Plasmodium malariae from 4 African countries.JCI insight · 2026Article
- Hidden hematological, biochemical and immune costs of asymptomatic malaria infections in semi-wild chimpanzees.PLoS pathogens · 2026Article
- Molecular Screening ofAnimals : an open access journal from MDPI · 2025Article
- First report of a Plasmodium malariae SSU rRNA gene variant in Africa associated with reduced amplification by nested PCR.Tropical medicine and health · 2025Article
- Assessing the Knowledge and Experience of Healthcare Workers in Zoonoses and the One Health Approach: A Cross-Sectional Study in Ghana.Environmental health insights · 2025Article
- Genome sequencing of Plasmodium malariae identifies continental segregation and mutations associated with reduced pyrimethamine susceptibility.Nature communications · 2024Article
- Remarkable Evolutionary Rate Variations Among Lineages and Among Genome Compartments in Malaria Parasites of Mammals.Molecular biology and evolution · 2024Article
- Origin of the human malaria parasite Plasmodium vivax.Trends in parasitology · 2024Review
- The Genome of Plasmodium gonderi: Insights into the Evolution of Human Malaria Parasites.Genome biology and evolution · 2024Article
- Epidemiological characteristics of Plasmodium malariae malaria in China: a malaria that should not be neglected post elimination.Infectious diseases of poverty · 2023Article
- Unusually Divergent Ubiquitin Genes and Proteins in Plasmodium Species.Genome biology and evolution · 2023Article
- Grand challenges in parasite epidemiology and ecology.Frontiers in parasitology · 2022Article
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Authors and funding
19 authors at 7 institutions in 5 countries.
Funding
Abstract
The human parasite Plasmodium malariae has relatives infecting African apes (Plasmodium rodhaini) and New World monkeys (Plasmodium brasilianum), but its origins remain unknown. Using a novel approach to characterise P. malariae-related sequences in wild and captive African apes, we found that this group comprises three distinct lineages, one of which represents a previously unknown, highly divergent species infecting chimpanzees, bonobos and gorillas across central Africa. A second ape-derived lineage is much more closely related to the third, human-infective lineage P. malariae, but exhibits little evidence of genetic exchange with it, and so likely represents a separate species. Moreover, the levels and nature of genetic polymorphisms in P. malariae indicate that it resulted from the zoonotic transmission of an African ape parasite, reminiscent of the origin of P. falciparum. In contrast, P. brasilianum falls within the radiation of human P. malariae, and thus reflects a recent anthroponosis.
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