Evidence map›Paper›PMID 35387820›Full record

ArticleBMJ open2022

Stillbirth, neonatal and maternal mortality among caesarean births in Kenya and Uganda: a register-based prospective cohort study.

Rakesh Ghosh, Nicole Santos, Elizabeth Butrick, Anthony Wanyoro, Peter Waiswa, Eliana Kim, Dilys Walker

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03112018 (Strengthening Intrapartum and Immediate Newborn Care to Reduce Morbidity and Mortality of Preterm Infants in Health Facilities in Migori County, Kenya and Busoga Region, Uganda), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03112018 nacompletednot on this map

Strengthening Intrapartum and Immediate Newborn Care to Reduce Morbidity and Mortality of Preterm Infants in Health Facilities in Migori County, Kenya and Busoga Region, Uganda: an Implementation Science RCT

TypeinterventionalSponsorUniversity of California, San FranciscoRan2016 to 2019Enrolled102,988ConditionsPregnancy Complications, Preterm Labor, PreTerm Birth, StillbirthArmsdata strengthening, modified Safe childbirth checklist - control, modified Safe childbirth checklist - enhanced, PRONTO training, QI cycles
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Perinatal mortality in eastern Africa: A systematic review and meta-analysis.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Pooled it
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Rakesh Ghosh *Institute for Global Health Sciences, University of California San Francisco, San Francisco, California, USA Rakesh.Ghosh@ucsf.edu.ORCID 0000-0002-7839-4148
Nicole Santos *Institute for Global Health Sciences, University of California San Francisco, San Francisco, California, USA.
Elizabeth ButrickUniversity of California San Francisco, San Francisco, California, USA.
Anthony WanyoroDepartment of OB/GYN, Kenyatta University, Nairobi, Kenya.
Peter WaiswaSchool of Public Health, Makerere University, Kampala, Uganda.
Eliana KimUniversity of California San Francisco, San Francisco, California, USA.
Dilys WalkerInstitute for Global Health Sciences, University of California San Francisco, San Francisco, California, USA.
University of California, San Francisco · USKenyatta University · KEMakerere University · UG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the interaction of risks for adverse maternal and perinatal outcomes (stillbirth, predischarge neonatal and maternal mortality) among caesarean section (CS) compared with vaginal deliveries (VD).

designProspective cohort study.

setting10 CS-capable facilities in Busoga Region, East-Central Uganda and Migori County, Kenya.

participantsIndividual birth data were extracted from maternity registers between October 2016 and April 2019. There were a total of 77 242 livebirths and 3734 stillbirths. Overall, 24% of deliveries were by CS with a range of 9%-49% across facilities. PRIMARY OUTCOME MEASURES: Stillbirth, predischarge neonatal mortality and maternal mortality.

resultsThe adjusted ORs for stillbirth, predischarge neonatal mortality and maternal mortality after a CS were 1.3 (95% CI 1.1 to 1.6), 1.9 (95% CI 1.6 to 2.2) and 3.3 (95% CI 2.2 to 4.9), respectively, compared with a VD. The association between maternal mortality and CS was 3.9 (95% CI 2.8 to 5.5) when the delivery was a live birth and 1.7 (95% CI 1.0 to 3.0) when it was a stillbirth. Post hoc analyses showed that mothers who received a CS had a lower risk of stillbirth if they were documented as a referral.

conclusionIn this context, CS births were at higher risk for worse outcomes compared with VD. Better understanding of CS use and associated adverse outcomes within the mother-baby dyad is necessary to identify opportunities to improve quality of intrapartum care. TRIAL REGISTRATION NUMBER: NCT03112018.

Indexed as

Maternal MortalityStillbirthCesarean SectionFemaleHumansInfant MortalityInfant, NewbornKenyaPregnancyProspective StudiesUgandaepidemiologyobstetricsquality in health care

Identifiers

PMID35387820
PMCPMC8987792
OpenAlexW4223627307

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.