ArticleJACC. Clinical electrophysiology2022
Clinical Impact of Residual Leaks Following Left Atrial Appendage Occlusion: Insights From the NCDR LAAO Registry.
Article in JACC. Clinical electrophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
85 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Risk factors, clinical implications, and management of peridevice leak following left atrial appendage closure: A systematic review.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Pooled it
- 2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.Journal of the American College of Cardiology · 2024Guideline
- Guideline
- Clinical efficacy and safety comparison of Watchman device versus ACP/Amulet device for percutaneous left atrial appendage closure in patients with nonvalvular atrial fibrillation: A study-level meta-analysis of clinical trials.Clinical cardiology · 2023Pooled it
- An updated meta-analysis of device related thrombus following left atrial appendage closure in patients with atrial fibrillation.Frontiers in cardiovascular medicine · 2022Pooled it
- Mechanisms, predictors, and evolution of severe peri-device leaks with two different left atrial appendage occluders.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Trial
- Left Atrial Appendage Closure: Past, Present, and Future.The Journal of innovations in cardiac rhythm management · 2026Review
- Sub-Zero: A Review of the Current Evidence and Evolving Technologies Enabling Zero‑Fluoroscopy Procedures.Pacing and clinical electrophysiology : PACE · 2026Review
- Patterns of antithrombotic treatment after left atrial appendage occlusion.Heart rhythm · 2026Article
- Percutaneous Retrieval Strategies Following Left Atrial Appendage Occluder and Peri-Device Leak Closure Embolization.JACC. Case reports · 2026Article
- Mixed Reality-Assisted Planning Enables Successful Coil Embolization of Anatomically Complex Peridevice Leak After LAAC.Anatolian journal of cardiology · 2026Article
- Scoring Goals: Peri-Device Leak Management in Transcatheter Left Atrial Appendage Closure.JACC. Case reports · 2026Article
- Article
- Procedural Outcome and Long-Term Follow-Up of Patients Undergoing Epicardial or Endocardial Left Atrial Appendage Occlusion.Journal of clinical medicine · 2026Article
- Percutaneous left atrial appendage closure for stroke prevention: current challenges and future perspectives.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Review
- Occlusion effects, safety, and clinical prognosis of Watchman and LAmbre occluders in left atrial appendage closure.BMC cardiovascular disorders · 2026Article
- CT-based radiomics to predict peri-device leakage after left atrial appendage closure.BMC medical imaging · 2026Article
- Bigger May Be Better Indeed?: Navigating Device Sizing in Left Atrial Appendage Closure.JACC. Asia · 2026Article
- Pulsed Field Versus Radiofrequency Ablation in Concomitant Pulmonary Vein Isolation and LAA Occlusion: Impact on Peridevice Leak and Procedural Efficiency.Journal of cardiovascular electrophysiology · 2026Article
- Effect of Device Size on Outcomes Following Left Atrial Appendage Closure in Borderline-Sized Anatomy.JACC. Asia · 2026Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
9 authors.
Funding
Abstract
backgroundData on the impact of residual peri-device leak after left atrial appendage occlusion (LAAO) are limited.
objectivesThe goal of this study was to explore the association of peri-device leak with adverse clinical events.
methodsThe National Cardiovascular Data Registry LAAO Registry was queried to identify patients undergoing LAAO between January 1, 2016, and December 31, 2019. Patients were classified according to leak size on echocardiography at 45 ± 14 days (0 mm, no leak; >0-5 mm, small leak; and >5 mm, large leak).
resultsA total of 51,333 patients were included, of whom 37,696 (73.4%) had no leak, 13,258 (25.8%) had small leaks, and 379 (0.7%) had large leaks. The proportion of patients on warfarin at 45 days was higher in the large vs small or no leak cohorts (44.9% vs 34.4% and 32.4%, respectively; P < 0.001). At 6 and 12 months, anticoagulant utilization decreased but remained more frequent in patients with large leaks. Thromboembolic and bleeding events were uncommon in all groups. However, compared with patients with no leak, those with small leaks had slightly higher odds of stroke/transient ischemic attack/systemic embolization (adjusted HR: 1.152; 95% CI: 1.025-1.294), major bleeding (HR: 1.11; 95% CI: 1.029-1.120), and any major adverse events (HR: 1.102; 95% CI: 1.048-1.160). There were no significant differences in adverse events between patients with large leaks and patients with small or no leaks.
conclusionsSmall (>0-5 mm) leaks after LAAO were associated with a modestly higher incidence of thromboembolic and bleeding events; large leaks (>5 mm) were not associated with adverse events, although higher proportions of these patients were maintained on anticoagulation. Newer devices with improved seal might mitigate the events associated with residual leaks.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.