Evidence map›Paper›PMID 35387686›Full record

Trial reportAdvances in rheumatology (London, England)2022

Dietetic intervention in psoriatic arthritis: the DIETA trial.

Beatriz F Leite, Melissa A Morimoto, Carina M F Gomes, Barbara N C Klemz, Patrícia S Genaro, Nittin Shivappa, James R Hébert, Nágila R T Damasceno, Marcelo M Pinheiro

Registry-linked trialOpen access · diamondAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Advances in rheumatology (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03142503 (Effectiveness of a Dietary Intervention Program on Disease Activity, Metabolism and Oxidative Stress in Patients With Psoriatic Arthritis and Psoriasis Activity), which is not on this map. Cited by 15 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 4 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03142503 nacompletednot on this map

Effectiveness of a Dietary Intervention Program on Disease Activity, Metabolism and Oxidative Stress in Patients With Psoriatic Arthritis and Psoriasis Activity: A Clinical, Randomized, Placebo-controlled Trial

TypeinterventionalSponsorFederal University of São PauloRan2013 to 2015Enrolled194ConditionsArthritis, Psoriatic, Metabolic SyndromeArmsDiet + supplementation, Diet + placebo, Placebo
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Impact of weight-loss interventions on psoriasis severity: A systematic review and meta-analysis.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
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  6. Lifestyle Modification for the Management of Psoriatic Arthritis.American journal of lifestyle medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Beatriz F LeiteRheumatology Division, Universidade Federal de São Paulo, Escola Paulista de Medicina (UNIFESP/EPM), 204 Leandro Dupré St., Room 74, Vila Clementino, Sao Paulo, SP, 04025-010, Brazil. leitebf@gmail.com.ORCID 0000-0002-7603-443X
Melissa A MorimotoRheumatology Division, Universidade Federal de São Paulo, Escola Paulista de Medicina (UNIFESP/EPM), 204 Leandro Dupré St., Room 74, Vila Clementino, Sao Paulo, SP, 04025-010, Brazil.
Carina M F GomesRheumatology Division, Universidade Federal de São Paulo, Escola Paulista de Medicina (UNIFESP/EPM), 204 Leandro Dupré St., Room 74, Vila Clementino, Sao Paulo, SP, 04025-010, Brazil.
Barbara N C KlemzRheumatology Division, Universidade Federal de São Paulo, Escola Paulista de Medicina (UNIFESP/EPM), 204 Leandro Dupré St., Room 74, Vila Clementino, Sao Paulo, SP, 04025-010, Brazil.
Patrícia S GenaroDepartment of Nutrition, Vale Do Paraíba University, 2911 Shishima Hifumi Av, Urbanova, Sao Jose dos Campos, São Paulo, 12244-000, Brazil.
Nittin ShivappaCancer Prevention and Control Program and Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA.
James R HébertCancer Prevention and Control Program and Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA.
Nágila R T DamascenoNutrition Department, Public Health School, Sao Paulo University, 715 Dr Arnaldo Av, Pacaembu, São Paulo, SP, 01246-904, Brazil.
Marcelo M PinheiroRheumatology Division, Universidade Federal de São Paulo, Escola Paulista de Medicina (UNIFESP/EPM), 204 Leandro Dupré St., Room 74, Vila Clementino, Sao Paulo, SP, 04025-010, Brazil.
Universidade Federal de São Paulo · BRUniversity of South Carolina · USUniversidade do Vale do Paraíba · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate whether dietary pattern changes, antioxidant supplementation or 5-10% weight loss could improve disease activity (skin and joint) in patients with psoriatic arthritis (PsA).

methodsA total of 97 PsA patients were enrolled in this 12-week randomized, double-blinded, placebo-controlled trial. Patients were randomized into three groups: Diet-placebo (hypocaloric diet + placebo supplementation); Diet-fish (hypocaloric diet + 3 g/day of omega-3 supplementation; and Placebo. Food intake (3-day registry, Healthy Eating Index (HEI), and the Dietary Inflammatory Index (DII)), body composition (whole-body dual-energy X-ray absorptiometry (DXA), weight and waist circumference) and disease activity (PASI, BSA, BASDAI, DAS28-ESR, DAS28-CRP and MDA) were evaluated at baseline and after the 12-week intervention. Statistical analysis used the intention-to-treat approach. The P value was considered to indicate significance when below 0.05.

resultsAfter 12 weeks, DAS28-CRP and BASDAI scores improved, especially in the Diet-placebo group (- 0.6 ± 0.9; p = 0.004 and - 1.39 ± 1.97; p = 0.001, respectively). In addition, a higher proportion of patients achieved minimal disease activity (MDA) in all groups. The Diet-fish group showed significant weight loss (- 1.79 ± 2.4; p = 0.004), as well as waist circumference (- 3.28 ± 3.5, p < 0.001) and body fat (- 1.2 ± 2.2, p = 0.006) reductions. There was no significant correlation between weight loss and disease activity improvement. Each 1-unit increase in the HEI value reduced the likelihood of achieving remission by 4%. Additionally, each 100-cal daily intake increase caused a 3.4-fold DAS28-ESR impairment.

conclusionA 12-week hypocaloric intervention provided suitable control of joint disease activity in patients with PsA, regardless of weight loss. Adding omega-3 supplementation caused relevant body composition changes but not disease activity improvement.

trial registrationThe study was recorded on Clinicaltrials.gov (NCT03142503).

Indexed as

Arthritis, PsoriaticDiet, ReducingHumansWeight LossAntioxidantBody composition measurementsDietFood intakePsoriatic arthritisRandomized clinical trial

Identifiers

PMID35387686
OpenAlexW4223633240

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.