Evidence map›Paper›PMID 35387663›Full record

ArticleMolecular brain2022

Assessments of prolonged effects of desflurane and sevoflurane on motor learning deficits in aged App

Ryo Niikura, Tomoyuki Miyazaki, Kenkichi Takase, Hiroki Sasaguri, Takashi Saito, Takaomi C Saido, Takahisa Goto

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular brain, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Ryo Niikura *Department of Anesthesiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Tomoyuki Miyazaki *Department of Anesthesiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan. johney@yokohama-cu.ac.jp.
Kenkichi TakaseLaboratory of Psychology, Jichi Medical University School of Medicine, Simotsuke, Tochigi, Japan. kenkichi.takase@jichi.ac.jp.
Hiroki SasaguriLaboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Saitama, Japan.
Takashi SaitoLaboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Saitama, Japan.
Takaomi C SaidoLaboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Saitama, Japan.
Takahisa GotoDepartment of Anesthesiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Yokohama City University · JPRIKEN Center for Brain Science · JPJichi Medical University · JPNagoya City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the proportion of elderly in society increases, so do the number of older patients undergoing surgical procedures. This is concerning as exposure to anesthesia has been identified as a risk factor for Alzheimer's disease (AD). However, the causal relationship between clinical AD development and anesthesia remains conjectural. Preclinical studies have demonstrated that anesthesia, such as halothane, isoflurane, and sevoflurane, induces AD-like pathophysiological changes and cognitive impairments in transgenic mouse models of AD. Desflurane does not have these effects and is expected to have more potential for use in elderly patients, yet little is known about its effects, especially on non-cognitive functions, such as motor and emotional functions. Thus, we examined the postanesthetic effects of desflurane and sevoflurane on motor and emotional function in aged App

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAgedAmyloid beta-Protein PrecursorAnimalsDesfluraneDisease Models, AnimalHumansMiceMice, Inbred C57BLMice, TransgenicSevofluraneAmyloid beta-PeptidesAmyloid beta-Protein PrecursorDesfluraneSevofluraneAlzheimer’s diseaseAppNL−G−F/NL−G−FBehavioral phenotypeGeneral anesthesiaPostanesthetic effectsTransgenic mice

Identifiers

PMID35387663
PMCPMC8988377
OpenAlexW4223607828

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.