Observational studyBMC medicine2022
The compensatory reserve index predicts recurrent shock in patients with severe dengue.
Observational study in BMC medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05938647 (Characteristics of Patients With Severe Dengue Admitted in Critical Care Units at Villavicencio, Colombia. A Retrospective Observational Trial.), which is not on this map. Cited by 8 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Characteristics of Patients With Severe Dengue Admitted in Critical Care Units at Villavicencio, Colombia. A Retrospective Observational Trial.
Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Artificial Intelligence Enabled Diagnostics Using Photoplethysmography (PPG): Beyond SpOLife (Basel, Switzerland) · 2026Review
- Serial bedside echocardiography identifies children at risk of recurrent Dengue shock: a prospective cohort study.BMC emergency medicine · 2026Article
- An artificial intelligence-based approach to identify volume status in patients with severe dengue using wearable PPG data.PLOS digital health · 2025Article
- Comparing the compensatory reserve metric obtained from invasive arterial measurements and photoplethysmographic volume-clamp during simulated hemorrhage.Journal of clinical monitoring and computing · 2024Article
- Predicting deterioration in dengue using a low cost wearable for continuous clinical monitoring.NPJ digital medicine · 2024Article
- Dengue.Lancet (London, England) · 2024Review
- The compensatory reserve index predicts recurrent shock in patients with severe dengue.BMC medicine · 2022Observational
- Review
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
Abstract
backgroundDengue shock syndrome (DSS) is one of the major clinical phenotypes of severe dengue. It is defined by significant plasma leak, leading to intravascular volume depletion and eventually cardiovascular collapse. The compensatory reserve Index (CRI) is a new physiological parameter, derived from feature analysis of the pulse arterial waveform that tracks real-time changes in central volume. We investigated the utility of CRI to predict recurrent shock in severe dengue patients admitted to the ICU.
methodsWe performed a prospective observational study in the pediatric and adult intensive care units at the Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. Patients were monitored with hourly clinical parameters and vital signs, in addition to continuous recording of the arterial waveform using pulse oximetry. The waveform data was wirelessly transmitted to a laptop where it was synchronized with the patient's clinical data.
resultsOne hundred three patients with suspected severe dengue were recruited to this study. Sixty-three patients had the minimum required dataset for analysis. Median age was 11 years (IQR 8-14 years). CRI had a negative correlation with heart rate and moderate negative association with blood pressure. CRI was found to predict recurrent shock within 12 h of being measured (OR 2.24, 95% CI 1.54-3.26), P < 0.001). The median duration from CRI measurement to the first recurrent shock was 5.4 h (IQR 2.9-6.8). A CRI cutoff of 0.4 provided the best combination of sensitivity and specificity for predicting recurrent shock (0.66 [95% CI 0.47-0.85] and 0.86 [95% CI 0.80-0.92] respectively).
conclusionCRI is a useful non-invasive method for monitoring intravascular volume status in patients with severe dengue.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.