Evidence map›Paper›PMID 35387630›Full record

ArticleBMC pediatrics2022

The incidence of eosinophilic oesophagitis in 2007-2017 among children in North Denmark Region is lower than expected.

Martin Hollænder, Jacob Holmen Terkelsen, Frederik Kramme, Kasper Bredal, Kristian Kragholm, Kasper Dalby, Søren Hagstrøm, Dorte Melgaard, Anne Lund Krarup

Open access · goldAbstract read
In one paragraph

Article in BMC pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Martin HollænderSchool of Medicine and Health, Aalborg University, Frederik Bajers Vej 7D, 9220, Aalborg, Denmark.
Jacob Holmen TerkelsenSchool of Medicine and Health, Aalborg University, Frederik Bajers Vej 7D, 9220, Aalborg, Denmark.
Frederik KrammeSchool of Medicine and Health, Aalborg University, Frederik Bajers Vej 7D, 9220, Aalborg, Denmark.
Kasper BredalSchool of Medicine and Health, Aalborg University, Frederik Bajers Vej 7D, 9220, Aalborg, Denmark.
Kristian KragholmDepartment of Cardiology, Unit of Clinical Biostatistics and Epidemiology, Aalborg University Hospital, Hobrovej 18-22, 9100, Aalborg, Denmark.
Kasper DalbyPediatric Center, Slotsgade 20C, 5000, Odense, Denmark.
Søren HagstrømDepartment of Pediatrics, Aalborg University Hospital, Hobrovej 18-22, 9100, Aalborg, Denmark.
Dorte MelgaardDepartment of Pediatrics, Aalborg University Hospital, Hobrovej 18-22, 9100, Aalborg, Denmark.
Anne Lund KrarupDepartment of Clinical Medicine, Aalborg University, Frederik Bajers Vej 7D, 9220, Aalborg, Denmark. apslk@rn.dk.
Aalborg University · DKAalborg University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn North Denmark Region (NDR), the incidence of Eosinophilic Oesophagitis (EoE) among adults has increased following a new biopsy protocol in 2011, whereas data on the incidence of EoE among children is lacking.

aimsTo describe the incidence of EoE in children aged 0-17 in NDR as well as diagnostic delay, clinical manifestations, treatment and complications.

methodsThis retrospective, register-based DanEoE cohort study included 18 children diagnosed with EoE between 2007-2017 in NDR. Medical files were reviewed with attention to symptoms, reason for referral, disease progress, treatment, symptomatic and histological remission as well as diagnostic delay.

resultsThe median incidence per year (2007-2017) was 0.86/100,000 children in NDR aged 0-17 years. The median diagnostic delay among children was four years and six months. Sixty percent presented with food impaction at first hospital visit. After initial treatment, only one of 18 children achieved symptomatic and histologic remission and had a long-term treatment plan.

conclusionsThe calculated incidence among children was lower compared to similar studies. Combined with poor remission rates and lack of follow-up, it is likely that EoE is an underdiagnosed and insufficiently treated disease among children in NDR. Our findings suggest that more knowledge concerning EoE in children could lead to a higher incidence, shorter diagnostic delay and more effective treatment.

Indexed as

Eosinophilic EsophagitisAdolescentAdultChildChild, PreschoolCohort StudiesDelayed DiagnosisDenmarkEnteritisEosinophiliaGastritisHumansIncidenceInfantInfant, NewbornRetrospective StudiesChildEosinophiliaEosinophilic oesophagitisIncidenceOesophagitisTreatment

Identifiers

PMID35387630
PMCPMC8985292
OpenAlexW4223425643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.