Evidence map›Paper›PMID 35387623›Full record

Observational studyBMC urology2022

Quality of life impact and recovery after ureteroscopy and stent insertion: insights from daily surveys in STENTS.

Jonathan D Harper, Alana C Desai, Jodi A Antonelli, Gregory E Tasian, Justin B Ziemba, Hussein R Al-Khalidi, H Henry Lai, Naim M Maalouf, Peter P Reese, Hunter B Wessells and 3 more

Registry-linked trialOpen access · goldAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in BMC urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06158620 (Intra-nasal Ketorolac Versus Oral Diclofenac for Acute Ureteral Stent-associated Pain Following Ureteroscopy for Stone Disease), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06158620 phase1 / phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Intra-nasal Ketorolac Versus Oral Diclofenac for Acute Ureteral Stent-associated Pain Following Ureteroscopy for Stone Disease

TypeinterventionalSponsorUniversity of Texas Southwestern Medical CenterRan2025 to 2027Enrolled80ConditionsPost Operative Pain, Urolithiasis, Ureter Calculi, Stent ComplicationArmsintra-nasal ketorolac, oral diclofenac
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 34 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 1 country.

Jonathan D Harper *Department of Urology, University of Washington School of Medicine, Seattle, WA, 98195, USA. jdharper@uw.edu.
Alana C Desai *Division of Urologic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO, USA.
Jodi A AntonelliDepartment of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Gregory E TasianDivision of Pediatric Urology, Department of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Justin B ZiembaDivision of Urology, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Hussein R Al-KhalidiDepartment of Biostatistics and Bioinformatics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.
H Henry LaiDivision of Urologic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO, USA.
Naim M MaaloufDepartment of Internal Medicine, Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Peter P ReeseRenal-Electrolyte and Hypertension Division, Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Hunter B WessellsDepartment of Urology, University of Washington School of Medicine, Seattle, WA, 98195, USA.
Ziya KirkaliNational Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
Charles D ScalesDepartments of Surgery and Population Health Science, Duke Surgical Center for Outcomes Research, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.
NIDDK Urinary Stone Disease Research Network (USDRN)
Clinical Research Institute · USThe University of Texas Southwestern Medical Center · USWashington University in St. Louis · USChildren's Hospital of Philadelphia · USHospital of the University of Pennsylvania · USNational Institute of Diabetes and Digestive and Kidney Diseases · USSeattle University · USUniversity of Pennsylvania · USUniversity of Washington · US

Funding

Optimizing Fluid Therapy and Stent Management in Children and Adults with NephrolithiasisU01DK110994 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI MAALOUF, NAIM M · 2016 to 2024
$5.3M
UW USDRN Clinical CenterU01DK110954 · NIDDK · UNIVERSITY OF WASHINGTON · PI HARPER, JONATHAN D., WESSELLS, HUNTER · 2016 to 2024
$4.9M
NIDDK NIH HHS U01 DK110954NIDDK NIH HHS U01 DK110994
6 · The paper itself

Abstract

backgroundOur objective was to describe day-to-day evolution and variations in patient-reported stent-associated symptoms (SAS) in the STudy to Enhance uNderstanding of sTent-associated Symptoms (STENTS), a prospective multicenter observational cohort study, using multiple instruments with conceptual overlap in various domains.

methodsIn a nested cohort of the STENTS study, the initial 40 participants having unilateral ureteroscopy (URS) and stent placement underwent daily assessment of self-reported measures using the Brief Pain Inventory short form, Patient-Reported Outcome Measurement Information System measures for pain severity and pain interference, the Urinary Score of the Ureteral Stent Symptom Questionnaire, and Symptoms of Lower Urinary Tract Dysfunction Research Network Symptom Index. Pain intensity, pain interference, urinary symptoms, and bother were obtained preoperatively, daily until stent removal, and at postoperative day (POD) 30.

resultsThe median age was 44 years (IQR 29,58), and 53% were female. The size of the dominant stone was 7.5 mm (IQR 5,11), and 50% were located in the kidney. There was consistency among instruments assessing similar concepts. Pain intensity and urinary symptoms increased from baseline to POD 1 with apparent peaks in the first 2 days, remained elevated with stent in situ, and varied widely among individuals. Interference due to pain, and bother due to urinary symptoms, likewise demonstrated high individual variability.

conclusionsThis first study investigating daily SAS allows for a more in-depth look at the lived experience after URS and the impact on quality of life. Different instruments measuring pain intensity, pain interference, and urinary symptoms produced consistent assessments of patients' experiences. The overall daily stability of pain and urinary symptoms after URS was also marked by high patient-level variation, suggesting an opportunity to identify characteristics associated with severe SAS after URS.

Indexed as

Lower Urinary Tract SymptomsUreterUreteral CalculiAdultFemaleHumansPainProspective StudiesQuality of LifeStentsSurveys and QuestionnairesUreteroscopyStent-associated symptomsUreteral stentUreteroscopyUrinary stone disease

Identifiers

PMID35387623
PMCPMC8988384
OpenAlexW4223551805

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.