ArticleBMC infectious diseases2022
Prehospital norepinephrine administration reduces 30-day mortality among septic shock patients.
Article in BMC infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Early norepinephrine for patients with septic shock: an updated systematic review and meta-analysis with trial sequential analysis.Critical care (London, England) · 2025Pooled it
- Early management of adult sepsis and septic shock: Korean clinical practice guidelines.Acute and critical care · 2024Guideline
- Effect of norepinephrine initiation timing on mortality in septic shock: a multicenter cohort study.BMC anesthesiology · 2026Observational
- Effect of timing of norepinephrine administration on prognosis of patients with septic shock: A prospective cohort study.Journal of intensive medicine · 2025Article
- Prehospital point-of-care medication burden as a predictor of poor related outcomes in unselected acute diseases.Internal and emergency medicine · 2025Article
- Diagnostic values of noradrenaline administered dose, procalcitonin (PCT) and blood lactic acid for septic shock.Journal of medical biochemistry · 2025Article
- Extremely early initiation of vasopressors might not decrease short-term mortality for adults with septic shock: a systematic review and meta-analysis.Annals of intensive care · 2025Article
- Septic shock in the prehospital setting: a scoping review.Scandinavian journal of trauma, resuscitation and emergency medicine · 2024Article
- The MINUTES bundle for the initial 30 min management of undifferentiated circulatory shock: an expert opinion.International journal of emergency medicine · 2024Review
- Sex- and Gender-Based Analysis on Norepinephrine Use in Septic Shock: Why Is It Still a Male World?Microorganisms · 2024Article
- The chain of survival and rehabilitation for sepsis: concepts and proposals for healthcare trajectory optimization.Annals of intensive care · 2024Review
- Should we initiate vasopressors earlier in patients with septic shock: A mini systemic review.World journal of critical care medicine · 2023Review
- 2023 Update on Sepsis and Septic Shock in Adult Patients: Management in the Emergency Department.Journal of clinical medicine · 2023Review
- Intensive care unit versus high-dependency care unit admission on mortality in patients with septic shock: let's think to the survival chain concept for septic shock.Journal of intensive care · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite differences in time of sepsis recognition, recent studies support that early initiation of norepinephrine in patients with septic shock (SS) improves outcome without an increase in adverse effects. This study aims to investigate the relationship between 30-day mortality in patients with SS and prehospital norepinephrine infusion in order to reach a mean blood pressure (MAP) > 65 mmHg at the end of the prehospital stage.
methodsFrom April 06th, 2016 to December 31th, 2020, patients with SS requiring prehospital Mobile Intensive Care Unit intervention (MICU) were retrospectively analysed. To consider cofounders, the propensity score method was used to assess the relationship between prehospital norepinephrine administration in order to reach a MAP > 65 mmHg at the end of the prehospital stage and 30-day mortality.
resultsFour hundred and seventy-eight patients were retrospectively analysed, among which 309 patients (65%) were male. The mean age was 69 ± 15 years. Pulmonary, digestive, and urinary infections were suspected among 44%, 24% and 17% patients, respectively. One third of patients (n = 143) received prehospital norepinephrine administration with a median dose of 1.0 [0.5-2.0] mg h
conclusionIn this study, we report that prehospital norepinephrine infusion in order to reach a MAP > 65 mmHg at the end of the prehospital stage is associated with a decrease in 30-day mortality in patients with SS cared for by a MICU in the prehospital setting. Further prospective studies are needed to confirm that very early norepinephrine infusion decreases septic shock mortality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.