Evidence map›Paper›PMID 35387603›Full record

ArticleBMC pregnancy and childbirth2022

Influences of gestational diabetes mellitus on the oral microbiota in offspring from birth to 1 month old.

Qiying Song, Bin Xiao, Hongli Huang, Liya Ma, Jian V Zhang, Yuanfang Zhu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. The oral microbiota and gestational diabetes mellitus.Frontiers in clinical diabetes and healthcare · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Qiying SongMaternal-Fetal Medicine Institute, Shenzhen Baoan Women's and Children's Hospital, Jinan University, No.56 Yulv Road, Baoan, 518100, Shenzhen, China.
Bin XiaoMaternal-Fetal Medicine Institute, Shenzhen Baoan Women's and Children's Hospital, Jinan University, No.56 Yulv Road, Baoan, 518100, Shenzhen, China.
Hongli HuangShenzhen Luohu Maternity and Child Health Care Hospital, Luohu, Shenzhen, 518019, China.
Liya MaDepartment of Child Healthcare, Shenzhen Baoan Women's and Children's Hospital, Jinan University, No.56 Yulv Road, Baoan, Shenzhen, 518100, China.
Jian V ZhangCenter for Energy Metabolism and Reproduction, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, No.1068 Xueyuan Avenue, Nanshan, 518055, Shenzhen, China. jian.zhang@siat.ac.cn.
Yuanfang ZhuMaternal-Fetal Medicine Institute, Shenzhen Baoan Women's and Children's Hospital, Jinan University, No.56 Yulv Road, Baoan, 518100, Shenzhen, China. zhuyf1027@163.com.
Jinan University · CNChinese Academy of Sciences · CNShenzhen Institutes of Advanced Technology · CN

Funding

Research Foundation of Shenzhen Baoan Women's and Children's Hospital, Jinan University BAFY 2021001Shenzhen Key Medical Discipline Construction Fund SZXK028
6 · The paper itself

Abstract

backgroundMaternal gestational diabetes mellitus (GDM) had long-term influences on the health of their children. However, the influences of GDM on the oral microbiota, which was closely related to oral and systemic health in offspring, were less documented. The present study aimed to explore the oral microbiota of neonates born to mothers with GDM is differentially colonized compared with those born to mothers without GDM, and whether any such differences persist to 1 month of age.

methodsOral samples were collected from children of mothers with (n = 20) and without GDM (n = 34) at birth and again at an average age of 1 month. The oral microbiota was characterized by 16S rRNA sequencing (V3-V4). Differences in diversity and composition according to maternal GDM status were assessed, and different metabolic functional pathways and microbial ecological networks were also analyzed.

resultsAlthough no significant differences were observed in diversity metrics between GDM and non-GDM groups (P > 0.05), we found significant differences in the taxonomic composition of oral microbiota from phylum to genus level between the two groups, with the GDM group exhibiting less abundance of Veillonella in both "Day 1" (P < 0.001) and "Day 30" (P < 0.05) phases. Metabolic pathways analysis showed that 5-aminoimidazole ribonucleotide biosynthesis and inosine-5'-phosphate biosynthesis were enriched in GDM subjects in the "Day 30" phase. Moreover, ecological network analysis revealed apparent differences between GDM and control groups, with the non-GDM group containing more high-degree nodes and microbial interactions compared with the GDM group.

conclusionMaternal GDM was associated with an altered oral microbial composition in neonates, although the distinct difference between GDM and non-GDM groups diminished in infancy. The oral microbiota functions and ecological networks differed dramatically between the two groups, highlighting the importance of maternal GDM status on initial oral microbiota in offspring.

Indexed as

Diabetes, GestationalGastrointestinal MicrobiomeMicrobiotaChildFemaleHumansInfantInfant, NewbornParturitionPregnancyRNA, Ribosomal, 16SRNA, Ribosomal, 16S16S rRNAGestational diabetes mellitusInfancyOral microbiota

Identifiers

PMID35387603
PMCPMC8988340
OpenAlexW4223611611

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.