Evidence map›Paper›PMID 35387543›Full record

ArticleXenobiotica; the fate of foreign compounds in biological systems2022

Oxidation of 3'-methoxyflavone, 4'-methoxyflavone, and 3',4'-dimethoxyflavone and their derivatives having 5,7-dihydroxyl moieties by human cytochromes P450 1B1 and 2A13.

Tsutomu Shimada, Haruna Nagayoshi, Norie Murayama, Atsuki Sawai, Vitchan Kim, Donghak Kim, Hiroshi Yamazaki, F Peter Guengerich, Shigeo Takenaka

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Xenobiotica; the fate of foreign compounds in biological systems, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Tsutomu ShimadaDepartment of Clinical Nutrition, Graduate School of Comprehensive Rehabilitation, Osaka Prefecture University, Osaka, Japan.ORCID 0000-0003-2552-4348
Haruna NagayoshiLaboratory of Food Sanitation, Osaka Institute of Public Health, Osaka, Japan.ORCID 0000-0002-8286-6056
Norie MurayamaLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Tokyo, Japan.
Atsuki SawaiDepartment of Clinical Nutrition, Graduate School of Comprehensive Rehabilitation, Osaka Prefecture University, Osaka, Japan.
Vitchan KimDepartment of Biological Sciences, Konkuk University, Seoul, Korea.
Donghak KimDepartment of Biological Sciences, Konkuk University, Seoul, Korea.ORCID 0000-0002-4421-7215
Hiroshi YamazakiLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Tokyo, Japan.ORCID 0000-0002-1068-4261
F Peter GuengerichDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA.ORCID 0000-0002-7458-3048
Shigeo TakenakaDepartment of Clinical Nutrition, Graduate School of Comprehensive Rehabilitation, Osaka Prefecture University, Osaka, Japan.
Osaka Prefecture University · JPKonkuk University · KRShowa Pharmaceutical University · JPOsaka Prefectural Institute of Public Health · JPVanderbilt University · US

Funding

Metabolism of Carcinogens and Drugs by Human P450sR01GM118122 · NIGMS · VANDERBILT UNIVERSITY · PI GUENGERICH, F PETER · 2016 to 2023
$3.3M
NIGMS NIH HHS R01 GM118122
6 · The paper itself

Abstract

Oxidation of 3'-methoxyflavone, 4'-methoxyflavone, and 3',4'-dimethoxyflavone and their derivatives containing 5,7-dihydroxyl groups by human cytochrome P450 (P450 or CYP) 1B1 and 2A13 was determined using LC-MS/MS systems.3'-Methoxyflavone and 4'-methoxyflavone were mainly

Indexed as

FlavonoidsTandem Mass SpectrometryChromatography, LiquidCytochrome P-450 CYP1B1Cytochrome P-450 Enzyme SystemFlavonesHumansMolecular Docking Simulation3',4'-dimethoxyflavone4'-methoxyflavoneCytochrome P-450 CYP1B1Cytochrome P-450 Enzyme SystemFlavonesFlavonoids3’,4’-dimethoxyflavoneCYP1B1CYP2A13LC-MS/MSmethoxylated flavonesoxidation

Identifiers

PMID35387543
PMCPMC9896170
OpenAlexW4223585177

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.