Evidence map›Paper›PMID 35387508›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2022

Recommendations for the use of propensity score methods in multiple sclerosis research.

Gabrielle Simoneau, Fabio Pellegrini, Thomas Pa Debray, Julie Rouette, Johanna Muñoz, Robert W Platt, John Petkau, Justin Bohn, Changyu Shen, Carl de Moor and 1 more

Abstract read
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gabrielle SimoneauBiogen Canada, Mississauga, ON, Canada.ORCID 0000-0001-9310-6274
Fabio PellegriniBiogen Spain, Madrid, Spain.
Thomas Pa DebrayUniversity Medical Center Utrecht, Utretch, The Netherlands.ORCID 0000-0002-1790-2719
Julie RouetteDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada/Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada.
Johanna MuñozUniversity Medical Center Utrecht, Utretch, The Netherlands.
Robert W PlattDepartment of Pediatrics, McGill University, Montreal, QC, Canada/Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada/Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada.
John PetkauDepartment of Statistics, The University of British Columbia, Vancouver, BC, Canada.
Justin BohnBiogen, Cambridge, MA, USA.
Changyu ShenBiogen, Cambridge, MA, USA.
Carl de MoorBiogen, Cambridge, MA, USA.
Mohammad Ehsanul KarimSchool of Population and Public Health, The University of British Columbia, Vancouver, BC, Canada/Centre for Health Evaluation and Outcome Sciences, The University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0002-0346-2871

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWith many disease-modifying therapies currently approved for the management of multiple sclerosis, there is a growing need to evaluate the comparative effectiveness and safety of those therapies from real-world data sources. Propensity score methods have recently gained popularity in multiple sclerosis research to generate real-world evidence. Recent evidence suggests, however, that the conduct and reporting of propensity score analyses are often suboptimal in multiple sclerosis studies.

objectivesTo provide practical guidance to clinicians and researchers on the use of propensity score methods within the context of multiple sclerosis research.

methodsWe summarize recommendations on the use of propensity score matching and weighting based on the current methodological literature, and provide examples of good practice.

resultsStep-by-step recommendations are presented, starting with covariate selection and propensity score estimation, followed by guidance on the assessment of covariate balance and implementation of propensity score matching and weighting. Finally, we focus on treatment effect estimation and sensitivity analyses.

conclusionThis comprehensive set of recommendations highlights key elements that require careful attention when using propensity score methods.

Indexed as

Multiple SclerosisHumansPropensity ScoreComparative effectivenesscovariate selectioninverse probability of treatment weightingobservational studypropensity score matchingreal-world data

Identifiers

PMID35387508
PMCPMC9260471

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.