Evidence map›Paper›PMID 35387344›Full record

ArticleFrontiers in pharmacology2022

PDE4B Is a Homeostatic Regulator of Cyclic AMP in Dendritic Cells.

Amy M Chinn, Cristina Salmerón, Jihyung Lee, Krishna Sriram, Eyal Raz, Paul A Insel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Amy M ChinnDepartment of Pharmacology, University of California, San Diego, La Jolla, CA, United States.
Cristina SalmerónDepartment of Pharmacology, University of California, San Diego, La Jolla, CA, United States.
Jihyung LeeDepartment of Medicine, University of California, San Diego, La Jolla, CA, United States.
Krishna SriramDepartment of Pharmacology, University of California, San Diego, La Jolla, CA, United States.
Eyal RazDepartment of Medicine, University of California, San Diego, La Jolla, CA, United States.
Paul A InselDepartment of Pharmacology, University of California, San Diego, La Jolla, CA, United States.
University of California, San Diego · US

Funding

A novel pathway of Th17/Th2 induction: The role of cAMP signaling in DCR01HL141999 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RAZ, EYAL, WEBSTER, NICHOLAS J · 2019 to 2022
$2.9M
NHLBI NIH HHS R01 HL141999
6 · The paper itself

Abstract

Chronic decreases in the second messenger cyclic AMP (cAMP) occur in numerous settings, but how cells compensate for such decreases is unknown. We have used a unique system-murine dendritic cells (DCs) with a DC-selective depletion of the heterotrimeric GTP binding protein Gα

Indexed as

compensationcyclic AMP (cAMP)PDE4Bphosphodiesterase (PDE)Th2 immunity

Identifiers

PMID35387344
PMCPMC8977838
OpenAlexW4220682786

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.