ArticleCardiovascular therapeutics2022
Effects of Vitamin D Deficiency on the Function of the Cardiac Autonomic Nervous System in Rats.
Article in Cardiovascular therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Shining Light on Dysautonomia: The Role of Vitamin D in Cardiac Autonomic Regulation.Current nutrition reports · 2026Review
- Association of Vitamin D Deficiency With Abnormal Electrocardiographic Activity Among Healthy People.Food science & nutrition · 2025Review
- Nonlinear Association Between Serum 25-Hydroxyvitamin D and Cardiac Autonomic Dysfunction in Diabetic Foot: A Threshold Effect on Heart Rate Variability.Journal of diabetes · 2025Article
- 25-hydroxyvitamin D as a predictor of reduced heart rate variability in elderly patients with diabetes mellitus.Frontiers in endocrinology · 2025Article
- Associations of vitamin D with coronary revascularization and heart rate variability in hypertensive patients.Frontiers in cardiovascular medicine · 2025Article
- Remodeling of the Intracardiac Ganglia During the Development of Cardiovascular Autonomic Dysfunction in Type 2 Diabetes: Molecular Mechanisms and Therapeutics.International journal of molecular sciences · 2024Review
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Authors and funding
7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Previous studies have shown that autonomic nervous system (ANS) dysfunction was closely related to vitamin D (VD) deficiency, but the mechanism remained unclear. The purpose of this study was to evaluate the mechanism of VD Methods: After 10 weeks of VD deficiency feeding, we successfully established a VD-deficient rat model. The body weight of rats was recorded, and the levels of calcium (Ca), phosphorus (P), creatinine (CRE), triglyceride (TG), hemoglobin (HG), and 25(OH)VD3 in serum were detected by corresponding kits. Short-time frequency domain analysis was used to evaluate the heart rate variability (HRV) of all rats. The expression of tyrosine hydroxylase (TH) in the atria and ventricle were detected by IHC. ELISA was used to determine the levels of acetyl choline (Ach) and nitric oxide (NO). HPLC was used for the detection of norepinephrine (NE). The expressions of KIR3.1, HERG, KVLQT1, and Mink were detected by qRT-PCR and western blot. Results: After 10 weeks of VD deficiency feeding, serum 25(OH)VD3 levels were markedly reduced in the VD Conclusion: VD deficiency leads to cardiac ANS dysfunction. The imbalance in heart rate variability, impaired release and secretion of neurotransmitters and local plasma hormones in the heart, and downregulation of potassium channel protein expression caused by VD deficiency may be closely related to this dysfunction.
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