Evidence map›Paper›PMID 35387169›Full record

ArticleBioactive materials2022

Sustained delivery of rhMG53 promotes diabetic wound healing and hair follicle development.

Hong Niu, Haichang Li, Ya Guan, Xin Zhou, Zhongguang Li, Serana Li Zhao, Peng Chen, Tao Tan, Hua Zhu, Valerie Bergdall and 3 more

Open access · goldAbstract read
In one paragraph

Article in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 36 citations in OpenAlex.

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  14. Peptide CyZoological research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Hong NiuDepartment of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO, 63130, USA.
Haichang LiDepartment of Surgery, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
Ya GuanDepartment of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO, 63130, USA.
Xin ZhouDepartment of Surgery, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
Zhongguang LiDepartment of Surgery, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
Serana Li ZhaoDepartment of Surgery, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
Peng ChenDepartment of Surgery, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
Tao TanDepartment of Surgery, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
Hua ZhuDepartment of Surgery, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
Valerie BergdallDepartment of Veterinary Preventive Medicine, University Laboratory Animals Resources, The Ohio State University, Columbus, OH, 43210, USA.
Xuehong XuLaboratory of Cell Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi'an, 710062, China.
Jianjie MaDepartment of Surgery, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, 43210, USA.
Jianjun GuanDepartment of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO, 63130, USA.
Lung Institute · USWashington University in St. Louis · USShaanxi Normal University · CNThe Ohio State University · US

Funding

Development of a protein therapeutics to counteract mustard-induced skin injuryR21AR080628 · NIAMS · OHIO STATE UNIVERSITY · PI LI, HAICHANG · 2022 to 2023
$433k
NIAMS NIH HHS R21 AR080628
6 · The paper itself

Abstract

MG53 is an essential component of the cell membrane repair machinery, participating in the healing of dermal wounds. Here we develop a novel delivery system using recombinant human MG53 (rhMG53) protein and a reactive oxygen species (ROS)-scavenging gel to treat diabetic wounds. Mice with ablation of MG53 display defective hair follicle structure, and topical application of rhMG53 can promote hair growth in the

Indexed as

Controlled drug deliveryDiabetic wound healinghair follicle stem cellMG53ROS-Scavenging hydrogel

Identifiers

PMID35387169
PMCPMC8961467
OpenAlexW4221052203

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.