Evidence map›Paper›PMID 35387157›Full record

ArticleBioactive materials2022

pH and lipase-responsive nanocarrier-mediated dual drug delivery system to treat periodontitis in diabetic rats.

Lu Wang, Yuzhou Li, Mingxing Ren, Xu Wang, Lingjie Li, Fengyi Liu, Yiqing Lan, Sheng Yang, Jinlin Song

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
12.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 83 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Lu WangCollege of Stomatology, Chongqing Medical University, Chongqing, China.
Yuzhou LiCollege of Stomatology, Chongqing Medical University, Chongqing, China.
Mingxing RenChongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, China.
Xu WangCollege of Stomatology, Chongqing Medical University, Chongqing, China.
Lingjie LiChongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, China.
Fengyi LiuCollege of Stomatology, Chongqing Medical University, Chongqing, China.
Yiqing LanChongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, China.
Sheng YangCollege of Stomatology, Chongqing Medical University, Chongqing, China.
Jinlin SongCollege of Stomatology, Chongqing Medical University, Chongqing, China.
The Affiliated Yongchuan Hospital of Chongqing Medical University · CNChongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precise and controlled drug delivery to treat periodontitis in patients with diabetes remains a significant clinical challenge. Nanoparticle-based drug delivery systems offer a potential therapeutic strategy; however, the low loading efficiency, non-responsiveness, and single effect of conventional nanoparticles hinder their clinical application. In this study, we designed a novel self-assembled, dual responsive, and dual drug-loading nanocarrier system, which comprised two parts: the hydrophobic lipid core formed by 1, 2-Distearoyl-sn-glycero-3-phosphoethanolamine-Poly (ethylene glycol) (DSPE-PEG) loaded with alpha-lipoic acid (ALA); and a hydrophilic shell comprising a poly (amidoamine) dendrimer (PAMAM) that electrostatically adsorbed minocycline hydrochloride (Mino). This unique design allows the controlled release of antioxidant/ALA under lipase stimulation from periodontal pathogens and antimicrobial/Mino under the low pH of the inflammatory microenvironment.

Indexed as

Bone lossDiabetes mellitusDrug deliveryPAMAMPeriodontitis

Identifiers

PMID35387157
PMCPMC8961308
OpenAlexW4213305258

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.